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Título: | Functional evidence for the inflammatory reflex in teleosts: A novel α7 nicotinic acetylcholine receptor modulates the macrophage response to dsRNA |
Autor: | Torrealba, Débora; Balasch, Joan Carles; Criado, Manuel CSIC ORCID; Tort, Lluís; Mackenzie, Simon; Roher, Nerea | Fecha de publicación: | 2018 | Editor: | Elsevier | Citación: | Developmental and Comparative Immunology 84: 279-291 (2018) | Resumen: | The inflammatory reflex modulates the innate immune system, keeping in check the detrimental consequences of overstimulation. A key player controlling the inflammatory reflex is the alpha 7 acetylcholine receptor (α7nAChR). This receptor is one of the signalling molecules regulating cytokine expression in macrophages. In this study, we characterize a novel teleost α7nAChR. Protein sequence analysis shows a high degree of conservation with mammalian orthologs and trout α7nAChR has all the features and essential amino acids to form a fully functional receptor. We demonstrate that trout macrophages can bind α-bungarotoxin (α-BTX), a competitive antagonist for α7nAChRs. Moreover, nicotine stimulation produces a decrease in pro-inflammatory cytokine expression after stimulation with poly(I:C). These results suggest the presence of a functional α7nAChR in the macrophage plasma membrane. Further, in vivo injection of poly(I:C) induced an increase in serum ACh levels in rainbow trout. Our results manifest for the first time the functional conservation of the inflammatory reflex in teleosts. | Versión del editor: | https://doi.org/10.1016/j.dci.2018.02.020 | URI: | http://hdl.handle.net/10261/308169 | DOI: | 10.1016/j.dci.2018.02.020 | E-ISSN: | 1879-0089 |
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