Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/307157
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Severe impairment of patient-reported outcomes in patients with chronic hepatitis C virus infection seen in real-world practices across the world: Data from the global liver registry |
Autor: | Younossi, Zobair M.; Yu, Ming-Lung; El-Kassas, Mohamed; Esmat, Gamal; Castellanos Fernández, Marlen I.; Buti, Maria; Papatheodoridis, Georgios; Yilmaz, Yusuf; Isakov, Vasily; Duseja, Ajay; Méndez-Sánchez, Nahum; Hamid, Saeed; Gordon, Stuart C.; Romero-Gómez, Manuel CSIC ORCID CVN; Chan, Wah-Kheong; Ong, Janus P.; Younossi, Issah; Lam, Brain; Ziayee, Mariam; Nader, Fatema; Racila, Andrei; Henry, Linda; Stepanova, Maria | Palabras clave: | Work productivity Direct-acting antivirals Disease burden Quality of life Viral hepatitis |
Fecha de publicación: | nov-2022 | Editor: | John Wiley & Sons | Citación: | Journal of Viral Hepatitis 29(11): 1015-1025 (2022) | Resumen: | Cure of chronic hepatitis C (CHC) can lead to improvement of health-related quality of life and other patient-reported outcomes (PROs). While extensive PRO data for CHC patients who were enrolled in clinical trials are available, similar data for patients seen in real-world practices are scarce. Our aim was to assess PROs of CHC patients enrolled from real-world practices from different regions and to compare them with those enrolled in clinical trials. CHC patients seen in clinical practices and not receiving treatment were enrolled in the Global Liver Registry (GLR). Clinical and PRO (FACIT-F, CLDQ-HCV, WPAI) data were collected and compared with the baseline data from CHC patients enrolled in clinical trials. N = 12,171 CHC patients were included (GLR n = 3146, clinical trial subjects n = 9025). Patients were from 30 countries from 6 out of 7 Global Burden of Disease (GBD) super-regions. Compared with clinical trial enrollees, patients from GLR were less commonly enrolled from High-Income GBD super-region, older, more commonly female, less employed, had more type 2 diabetes, anxiety and clinically overt fatigue but less cirrhosis (all p < 0.001). Out of 15 PRO domain and summary scores, 12 were lower in GLR patients than in subjects enrolled in clinical trials (p < 0.001). In multiple regression models, anxiety, depression, and fatigue were associated with significant PRO impairment in CHC patients (p < 0.05). After adjustment for the clinico-demographic confounders, the association of PRO scores of CHC patients with enrolment settings was no longer significant (all p > 0.05). In conclusion, hepatitis C patients seen in the real-world practices have PRO impairment driven by fatigue and psychiatric comorbidities. | Versión del editor: | https://doi.org/10.1111/jvh.13741 | URI: | http://hdl.handle.net/10261/307157 | DOI: | 10.1111/jvh.13741 | ISSN: | 1352-0504 |
Aparece en las colecciones: | (IBIS) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 59,24 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
1
checked on 08-mar-2024
SCOPUSTM
Citations
2
checked on 19-abr-2024
WEB OF SCIENCETM
Citations
2
checked on 25-feb-2024
Page view(s)
22
checked on 27-abr-2024
Download(s)
3
checked on 27-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.