Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/305868
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Transcriptomic effects of Perfluoralkyl acids on the adipose tissue of a songbird species at environmentally relevant concentrations |
Autor: | Lopez-Antia, Ana; Piña, Benjamín CSIC ORCID ; Lacorte Bruguera, Silvia CSIC ORCID; Bervoets, Lieven; Eens, Marcel | Palabras clave: | Transcriptome Adipocytes Obesogens PFOA PFOS |
Fecha de publicación: | 25-mar-2023 | Editor: | Elsevier | Citación: | Environmental Pollution 327: 121478 (2023) | Resumen: | Perfluoralkyl acids (PFAS) have been regarded as global pollutants for at least twenty years, with potentially negative physiological effects on multiple vertebrate species including humans. Here we analyze the effects of the administration of environmentally-relevant levels of PFAS on caged canaries (Serinus canaria) by using a combination of physiological, immunological, and transcriptomic analyses. This constitutes a completely new approach to understand the toxicity pathway of PFAS in birds. While we observed no effects on physiological and immunological parameters (e.g, body weight, fat index, cell-mediated immunity), the transcriptome of the pectoral fatty tissue showed changes compatible with the known effects of PFAS as obesogens in other vertebrates, particularly in mammals. First, transcripts related to the immunological response were affected (mainly enriched), including several key signaling pathways. Second, we found a repression of genes related to the peroxisome response and fatty acid metabolism. We interpret these results as indicative of the potential hazard of environmental concentrations of PFAS on the fat metabolism and the immunological system of birds, while exemplifying the ability of transcriptomic analyses of detecting early physiological responses to toxicants. As the potentially affected functions are essential for the survival of the animals during, for example, migration, our results underline the need for tight control of the exposure of natural populations of birds to these substances. | Versión del editor: | https://doi.org/10.1016/j.envpol.2023.121478 | URI: | http://hdl.handle.net/10261/305868 | DOI: | 10.1016/j.envpol.2023.121478 | ISSN: | 02697491 |
Aparece en las colecciones: | (IDAEA) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | Existing users please Login |
---|---|---|---|---|
1-s2.0-S0269749123004803-main.pdf | Artículo principal | 2,86 MB | Adobe PDF | Embargoed until 15 de junio de 2025 Petición de una copia |
1-s2.0-S0269749123004803-mmc1.docx | Material suplementario | 421,86 kB | Microsoft Word XML | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
1
checked on 21-abr-2024
Page view(s)
56
checked on 26-abr-2024
Download(s)
5
checked on 26-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.