Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/295380
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Insulin-like growth factor I sensitization rejuvenates sleep patterns in old mice |
Autor: | Zegarra-Valdivia, Jonathan A. CSIC ORCID; Fernandes, Jansen CSIC; Fernandez de Sevilla, M.E. CSIC ORCID; Trueba Saiz, Ángel CSIC; Pignatelli, J.; Suda, K.; Martinez-Rachadell, Laura CSIC; Fernandez, A. M.; Esparza, Julio CSIC ORCID; Vega, M.; Nuñez, A.; Torres Alemán, Ignacio CSIC ORCID | Palabras clave: | Aging Cortical activation IGF-I Orexinergic neurons Sleep Rejuvenation |
Fecha de publicación: | 2022 | Editor: | Springer Nature | Citación: | GeroScience 44: 2243- 2257 (2022) | Resumen: | Sleep disturbances are common during aging. Compared to young animals, old mice show altered sleep structure, with changes in both slow and fast electrocorticographic (ECoG) activity and fewer transitions between sleep and wake stages. Insulin-like growth factor I (IGF-I), which is involved in adaptive changes during aging, was previously shown to increase ECoG activity in young mice and monkeys. Furthermore, IGF-I shapes sleep architecture by modulating the activity of mouse orexin neurons in the lateral hypothalamus (LH). We now report that both ECoG activation and excitation of orexin neurons by systemic IGF-I are abrogated in old mice. Moreover, orthodromical responses of LH neurons are facilitated by either systemic or local IGF-I in young mice, but not in old ones. As orexin neurons of old mice show dysregulated IGF-I receptor (IGF-IR) expression, suggesting disturbed IGF-I sensitivity, we treated old mice with AIK3a305, a novel IGF-IR sensitizer, and observed restored responses to IGF-I and rejuvenation of sleep patterns. Thus, disturbed sleep structure in aging mice may be related to impaired IGF-I signaling onto orexin neurons, reflecting a broader loss of IGF-I activity in the aged mouse brain. | Versión del editor: | http://dx.doi.org/10.1007/s11357-022-00589-1 | URI: | http://hdl.handle.net/10261/295380 | DOI: | 10.1007/s11357-022-00589-1 | Identificadores: | doi: 10.1007/s11357-022-00589-1 issn: 2509-2723 |
Aparece en las colecciones: | (IC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
s11357-022-00589-1.pdf | 1,35 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
4
checked on 24-abr-2024
WEB OF SCIENCETM
Citations
4
checked on 28-feb-2024
Page view(s)
20
checked on 01-may-2024
Download(s)
92
checked on 01-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
Este item está licenciado bajo una Licencia Creative Commons