Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/286902
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | MacroH2As regulate enhancer-promoter contacts affecting enhancer activity and sensitivity to inflammatory cytokines |
Autor: | Corujo, David; Malinverni, Roberto; Carrillo-Reixach, Juan; Meers, Oliver; Garcia-Jaraquemada, Arce; Pannérer, Marguerite-Marie Le; Valero, Vanesa; Pérez, Ainhoa; Río-Álvarez, Álvaro Del; Royo, Laura CSIC; Pérez-González, Beatriz; Raurell, Helena; Acemel, Rafael D. CSIC ORCID; Santos-Pereira, José M. CSIC ORCID; Garrido-Pontnou, Marta; Gómez-Skarmeta, José Luis CSIC ORCID ; Pasquali, Lorenzo; Manyé, Josep; Armengol, Carolina; Buschbeck, Marcus | Palabras clave: | Epigenetics Chromatin regulation Histone variants MacroH2A Cancer Inflammation Hepatoblastoma |
Fecha de publicación: | 2022 | Editor: | Cell Press | Citación: | Cell Reports 39(12): 110988 (2022) | Resumen: | MacroH2A histone variants have a function in gene regulation that is poorly understood at the molecular level. We report that macroH2A1.2 and macroH2A2 modulate the transcriptional ground state of cancer cells and how they respond to inflammatory cytokines. Removal of macroH2A1.2 and macroH2A2 in hepatoblastoma cells affects the contact frequency of promoters and distal enhancers coinciding with changes in enhancer activity or preceding them in response to the cytokine tumor necrosis factor alpha. Although macroH2As regulate genes in both directions, they globally facilitate the nuclear factor κB (NF-κB)-mediated response. In contrast, macroH2As suppress the response to the pro-inflammatory cytokine interferon gamma. MacroH2A2 has a stronger contribution to gene repression than macroH2A1.2. Taken together, our results suggest that macroH2As have a role in regulating the response of cancer cells to inflammatory signals on the level of chromatin structure. This is likely relevant for the interaction of cancer cells with immune cells of their microenvironment. | Versión del editor: | http://dx.doi.org/10.1016/j.celrep.2022.110988 | URI: | http://hdl.handle.net/10261/286902 | DOI: | 10.1016/j.celrep.2022.110988 | Identificadores: | doi: 10.1016/j.celrep.2022.110988 issn: 2211-1247 |
Aparece en las colecciones: | (CABD) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
MacroH2As regulate_Corujo_PV_Art2022.pdf | 4,09 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
5
checked on 02-may-2024
WEB OF SCIENCETM
Citations
4
checked on 25-feb-2024
Page view(s)
61
checked on 13-may-2024
Download(s)
17
checked on 13-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
Este item está licenciado bajo una Licencia Creative Commons