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Título: | Mesenchymal stem cells delivery in individuals with different pathologies: multimodal tracking, safety and future applications |
Autor: | Belmar-Lopez, Carolina; Vassaux, Georges; Medel-Martínez, Ana; Burnet, Jerome; Quintanilla, Miguel CSIC ORCID; Ramón y Cajal, Santiago; Hernández-Losa, Javier; Vieja, Antonio de la CSIC ORCID; Martín-Duque, Pilar | Palabras clave: | Mesenchymal stem cells Sodium/iodide symporter (NIS) Transdifferentiation Therapy imaging PET SPECT Bioluminescence Luciferase Radioiodine therapy Diabetes Injuries |
Fecha de publicación: | 2022 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | International Journal of Molecular Sciences 23(3): 1682 (2022) | Resumen: | Due to their ease of isolation and their properties, mesenchymal stem cells (MSCs) have been widely investigated. MSCs have been proved capable of migration towards areas of inflammation, including tumors. Therefore, they have been suggested as vectors to carry therapies, specifically to neoplasias. As most of the individuals joining clinical trials that use MSCs for cancer and other pathologies are carefully recruited and do not suffer from other diseases, here we decided to study the safety and application of iv-injected MSCs in animals simultaneously induced with different inflammatory pathologies (diabetes, wound healing and tumors). We studied this by in vitro and in vivo approaches using different gene reporters (GFP, hNIS, and f-Luc) and non-invasive techniques (PET, BLI, or fluorescence). Our results found that MSCs reached different organs depending on the previously induced pathology. Moreover, we evaluated the property of MSCs to target tumors as vectors to deliver adenoviruses, including the interaction between tumor microenvironment and MSCs on their arrival. Mechanisms such as transdifferentiation, MSC fusion with cells, or paracrine processes after MSCs homing were studied, increasing the knowledge and safety of this new therapy for cancer. | Versión del editor: | http://dx.doi.org/10.3390/ijms23031682 | URI: | http://hdl.handle.net/10261/283930 | DOI: | 10.3390/ijms23031682 | Identificadores: | doi: 10.3390/ijms23031682 issn: 1661-6596 e-issn: 1422-0067 |
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Mesenchymal stem cells deliver_Belmar_PV_Art2022.pdf | 5,49 MB | Adobe PDF | Visualizar/Abrir |
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