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Título: | Differential expression of inflammatory and immune response genes in mesenteric lymph nodes of Iberian red deer (Cervus elaphus hispanicus) naturally infected with Mycobacterium bovis |
Autor: | Fernández de Mera, Isabel G. CSIC ORCID; Pérez de Lastra, José Manuel CSIC ORCID ; Ayoubi, Patricia; Naranjo, María Victoria CSIC ; Kocan, Katherine M.; Gortázar, Christian CSIC ORCID ; Fuente, José de la CSIC ORCID | Fecha de publicación: | 2008 | Editor: | Elsevier | Citación: | Developmental and Comparative Immunology 32(2): 85-91 (2008) | Resumen: | Little information is available about gene expression in natural mycobacterial infection of wildlife species. Iberian red deer can serve as reservoir of Mycobacterium bovis in Spain, thus increasing the risk of bovine tuberculosis (bTB) in humans and cattle. Herein, we characterized the differential expression of inflammatory and immune response genes in mesenteric lymph nodes of deer naturally infected with M. bovis using microarray hybridization. Results were validated by determination of serum protein concentrations and/or real-time RT-PCR. Of the 600 genes that were analyzed in the microarray, 17 genes displayed an expression fold change greater than 1.7 in infected or uninfected deer (P⩽0.05). These genes included tight junction proteins, IL-11R, bactenecin, CD62L, CD74, desmoglein, IgA and IgM that constitute new findings and suggest new mechanisms by which M. bovis may modulate host inflammatory and immune responses. These results contribute to our basic understanding of the mechanisms of pathogenesis and immunity to natural mycobacterial infections and may have important implications for the control of bTB. | Versión del editor: | https://doi.org/10.1016/j.dci.2007.05.001 | URI: | http://hdl.handle.net/10261/281996 | DOI: | 10.1016/j.dci.2007.05.001 | ISSN: | 0145-305X |
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