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Título: | Ultrasmall manganese ferrites for in vivo catalase mimicking activity and multimodal bioimaging |
Autor: | Carregal-Romero, Susana; Miguel-Coello, Ana Beatriz; Martínez-Parra, Lydia; Martí-Mateo, Yolanda; Hernansanz-Agustín, Pablo; Fernández-Afonso, Yilian CSIC ORCID; Plaza-García, Sandra CSIC; Gutiérrez, Lucía CSIC ORCID; Muñoz-Hernández, María del Mar; Carrillo-Romero, Juliana; Piñol-Cancer, Marina; Lecante, Pierre; Blasco-Iturri, Zuriñe; Fadón, Lucía; Almansa-García, Ana C.; Möller, Marco; Otaegui, Dorleta; Enríquez, Jose Antonio; Groult, Hugo; Ruíz-Cabello, Jesús | Fecha de publicación: | 2022 | Editor: | Wiley-VCH | Citación: | Small 18(16); 2106570 (2022) | Resumen: | Manganese ferrite nanoparticles display interesting features in bioimaging and catalytic therapies. They have been recently used in theranostics as contrast agents in magnetic resonance imaging (MRI), and as catalase-mimicking nanozymes for hypoxia alleviation. These promising applications encourage the development of novel synthetic procedures to enhance the bioimaging and catalytic properties of these nanomaterials simultaneously. Herein, a cost-efficient synthetic microwave method is developed to manufacture ultrasmall manganese ferrite nanoparticles as advanced multimodal contrast agents in MRI and positron emission tomography (PET), and improved nanozymes. Such a synthetic method allows doping ferrites with Mn in a wide stoichiometric range (MnxFe3-xO4, 0.1 ≤ x ≤ 2.4), affording a library of nanoparticles with different magnetic relaxivities and catalytic properties. These tuned magnetic properties give rise to either positive or dual-mode MRI contrast agents. On the other hand, higher levels of Mn doping enhance the catalytic efficiency of the resulting nanozymes. Finally, through their intracellular catalase-mimicking activity, these ultrasmall manganese ferrite nanoparticles induce an unprecedented tumor growth inhibition in a breast cancer murine model. All of these results show the robust characteristics of these nanoparticles for nanobiotechnological applications. | Versión del editor: | https://doi.org/10.1002/smll.202106570 | URI: | http://hdl.handle.net/10261/280840 | DOI: | 10.1002/smll.202106570 | E-ISSN: | 1613-6829 |
Aparece en las colecciones: | (INMA) Artículos |
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