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Título: | Light activated pulsatile drug delivery for prolonged peripheral nerve block |
Autor: | Prieto, Martín; Usón, Laura CSIC ORCID; Garcia-Salinas, Sara; Yus, Cristina CSIC ORCID; Landa, Guillermo CSIC ORCID; Alejo, Teresa CSIC ORCID; Luján, Lluís; Pérez-Miana, Marta CSIC; Irusta, Silvia CSIC ORCID CVN; Sebastián, Víctor CSIC ORCID; Mendoza, Gracia; Arruebo, Manuel CSIC ORCID | Fecha de publicación: | 2022 | Editor: | Elsevier | Citación: | Biomaterials 283: 121453 (2022) | Resumen: | Regional anesthesia is widely used in peripheral nerve block and in neuraxial anesthesia to reduce anesthetics systemic side effects and shorten recovery times. However, when applied as a single injection (e.g., peripheral nerve block) it is limited by the duration of its effect. Herein, we develop a thermoresponsive nanogel based on poly(oligoethylene glycol methacrylate) containing the long-lasting anesthetic bupivacaine, which can be externally activated by using near-infrared light due to the photothermal properties of hollow gold nanoparticles embedded in the nanogel which facilitate its phase transition, triggering drug release at a controlled temperature above body temperature. Bupivacaine in vitro release can be repeatedly triggered to achieve a controlled pulsatile release of the drug due to the reversible nature of the thermosensitive nanogel, achieving a spatio-temporal control of the release. In vivo sciatic nerve block demonstrates that whereas the administered dose of free bupivacaine produces sensory block and impaired motor function for 2 h, the equivalent bupivacaine dose included in the developed release system can significantly prolong its neurobehavioral anesthetic effect for over 6 h. This release system can also be reactivated multiple times by subsequent irradiation cycles without observing detrimental toxicity in the infiltrated tissues. | Versión del editor: | https://doi.org/10.1016/j.biomaterials.2022.121453 | URI: | http://hdl.handle.net/10261/280398 | DOI: | 10.1016/j.biomaterials.2022.121453 | E-ISSN: | 1878-5905 |
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