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Título: | Antimicrobial Resistance in the COVID-19 Landscape: Is There an Opportunity for Anti-Infective Antibodies and Antimicrobial Peptides? |
Autor: | Pérez de Lastra, José Manuel CSIC ORCID ; Anand, Uttpal; González-Acosta, Sergio CSIC ORCID; López, Manuel R. CSIC ORCID; Dey, Abhijit; Bontempi, Elza; Morales-delaNuez, Antonio CSIC ORCID | Palabras clave: | SARS-CoV-2 antibiotic resistance one health approach Global health antibiotic discovery antimicrobial peptides Environmental contamination vaccination |
Fecha de publicación: | 2-jun-2022 | Editor: | Frontiers Media | Citación: | Frontiers in Immunology, 13:921483 : 1-13 (2022) | Resumen: | Although COVID-19 has captured most of the public health attention, antimicrobial resistance (AMR) has not disappeared. To prevent the escape of resistant microorganisms in animals or environmental reservoirs a “one health approach” is desirable. In this context of COVID-19, AMR has probably been affected by the inappropriate or over-use of antibiotics. The increased use of antimicrobials and biocides for disinfection may have enhanced the prevalence of AMR. Antibiotics have been used empirically in patients with COVID-19 to avoid or prevent bacterial coinfection or superinfections. On the other hand, the measures to prevent the transmission of COVID-19 could have reduced the risk of the emergence of multidrug-resistant microorganisms. Since we do not currently have a sterilizing vaccine against SARS-CoV-2, the virus may still multiply in the organism and new mutations may occur. As a consequence, there is a risk of the appearance of new variants. Nature-derived anti-infective agents, such as antibodies and antimicrobial peptides (AMPs), are very promising in the fight against infectious diseases, because they are less likely to develop resistance, even though further investigation is still required. | Versión del editor: | https://doi.org/10.3389/fimmu.2022.921483 | URI: | http://hdl.handle.net/10261/279227 | DOI: | 10.3389/fimmu.2022.921483 | E-ISSN: | 1664-3224 |
Aparece en las colecciones: | (PTI Salud Global) Colección Especial COVID-19 (IPNA) Artículos |
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Antimicrobial-Perez_de_la_lastra_et_al-2022-Frontiers_in_immunology.pdf | 1,8 MB | Adobe PDF | Visualizar/Abrir |
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