Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/269461
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Delayed administration of ixazomib modifies the immune response and prevents chronic graft-versus-host disease |
Autor: | Lopes Ramos, Teresa CSIC ORCID; García-Guerrero, Estefanía CSIC ORCID; Caballero-Velázquez, Teresa CSIC ORCID; Rodríguez-Gil, Alfonso CSIC; Caracuel-García, Rocío CSIC; Nufer, Melanie; Robles-Frías, María José CSIC; Barbado, María Victoria CSIC ORCID; Pérez-Simón, José A. CSIC ORCID | Fecha de publicación: | 23-sep-2021 | Editor: | Springer Nature | Citación: | Bone Marrow Transplantation 56: 3049-3058 (2021) | Resumen: | In this study, we aimed to modify the immune response in the long term after allogeneic bone marrow transplantation (allo-BMT) by using the proteasome inhibitor ixazomib (IXZ) at the late stages of the post-transplant period. This approach facilitated the immune reconstitution after transplantation. IXZ significantly prolonged survival and decreased the risk of chronic graft-versus-host disease (cGvHD) in two different murine models without hampering the graft-versus-leukemia (GvL) effect, as confirmed by bioluminescence assays. Remarkably, the use of IXZ was related to an increase of regulatory T cells both in peripheral blood and in the GvHD target organs and a decrease of effector donor T cells. Regarding B cells, IXZ treated mice had faster recovery of B cells in PB and of pre-pro-B cells in the bone marrow. Mice receiving ixazomib had a lower number of neutrophils in the GvHD target organs as compared to the vehicle group. In summary, delayed administration of IXZ ameliorated cGvHD while preserving GvL and promoted a pro-tolerogenic immune response after allo-BMT. | Versión del editor: | http://dx.doi.org/10.1038/s41409-021-01452-1 | URI: | http://hdl.handle.net/10261/269461 | DOI: | 10.1038/s41409-021-01452-1 | Identificadores: | doi: 10.1038/s41409-021-01452-1 issn: 0268-3369 e-issn: 1476-5365 |
Aparece en las colecciones: | (IBIS) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
administration_ixazomib.pdf | 3,12 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
Page view(s)
52
checked on 27-abr-2024
Download(s)
35
checked on 27-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Este item está licenciado bajo una Licencia Creative Commons