Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/267794
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | One-year dietary supplementation with walnuts modifies exosomal miRNA in elderly subjects |
Autor: | López de las Hazas, María-Carmen; Gil-Zamorano, Judit; Cofán, Montserrat; Mantilla-Escalante, Diana C.; García-Ruiz, Almudena CSIC ORCID; del Pozo-Acebo, Lorena; Pastor, Óscar; Yáñez-Mó, María; Mazzeo, Carla; Serra-Mir, Mercè; Domenech, Monica; Valls-Pedret, Cinta; Rajaram, Sujatha; Sabaté, Joan; Ros, Emilio; Sala-Vila, Aleix; Dávalos, Alberto | Palabras clave: | c-miRNA Dietary intervention Exosomes Lipidomics Walnuts |
Fecha de publicación: | 26-sep-2020 | Editor: | Springer Nature | Citación: | European Journal of Nutrition 60: 1999- 2011 (2021) | Resumen: | Purpose: Epidemiological studies and clinical trials support the association of nut consumption with a lower risk of prevalent non-communicable diseases, particularly cardiovascular disease. However, the molecular mechanisms underlying nut benefits remain to be fully described. MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression and play a pivotal role in health and disease. Exosomes are extracellular vesicles released from cells and mediate intercellular communication. Whether nut consumption modulates circulating miRNAs (c-miRNAs) transported in exosomes is poorly described. Methods: Cognitively healthy elderly subjects were randomized to either control (n = 110, abstaining from walnuts) or daily supplementation with walnuts (15% of their total energy, ≈30–60 g/day, n = 101) for 1-year. C-miRNAs were screened in exosomes isolated from 10 samples, before and after supplementation, and identified c-miRNA candidates were validated in the whole cohort. In addition, nanoparticle tracking analysis and lipidomics were assessed in pooled exosomes from the whole cohort. Results: Exosomal hsa-miR-32-5p and hsa-miR-29b-3p were consistently induced by walnut consumption. No major changes in exosomal lipids, nanoparticle concentration or size were found. Conclusion: Our results provide novel evidence that certain c-miRNAs transported in exosomes are modulated by walnut consumption. The extent to which this finding contributes to the benefits of walnuts deserves further research. | Versión del editor: | http://dx.doi.org/10.1007/s00394-020-02390-2 | URI: | http://hdl.handle.net/10261/267794 | DOI: | 10.1007/s00394-020-02390-2 | Identificadores: | doi: 10.1007/s00394-020-02390-2 issn: 1436-6215 |
Aparece en las colecciones: | (CBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Yañez-MoM_One-yearDietarySupplementation.pdf | 1,39 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
Page view(s)
94
checked on 15-may-2024
Download(s)
329
checked on 15-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.