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http://hdl.handle.net/10261/261071
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dc.contributor.author | Aran, Andrea | - |
dc.contributor.author | Peg, Vicente | - |
dc.contributor.author | Rabanal, Rosa | - |
dc.contributor.author | Bernadó-Morales, Cristina | - |
dc.contributor.author | Zamora, Esther | - |
dc.contributor.author | Molina, Elisa | - |
dc.contributor.author | Arribas, Yago A. | - |
dc.contributor.author | Arribas, Joaquín | - |
dc.contributor.author | Pérez-García, José Manuel | - |
dc.contributor.author | Roura-Mir, Carme | - |
dc.contributor.author | Carrascal, Montserrat | - |
dc.contributor.author | Cortés, Javier | - |
dc.contributor.author | Martí, Mercè | - |
dc.date.accessioned | 2022-02-16T13:20:37Z | - |
dc.date.available | 2022-02-16T13:20:37Z | - |
dc.date.issued | 2021-11-16 | - |
dc.identifier | doi: 10.3389/fimmu.2021.761798 | - |
dc.identifier | e-issn: 1664-3224 | - |
dc.identifier.citation | Frontiers in Immunology 12: 761798 (2021) | - |
dc.identifier.uri | http://hdl.handle.net/10261/261071 | - |
dc.description.abstract | EBV-specific T cells have been recently described to be involved in fatal encephalitis and myocarditis in cancer patients after immune checkpoint therapies. Here, we report the study of a human triple-negative breast cancer tumor (TNBC) and EBV-transformed B cells obtained from a patient-derived xenograft (PDX) that progressed into a lymphocytic neoplasm named xenograft-associated B-cell lymphoma (XABCL). T-cell receptor (TCR) high-throughput sequencing was performed to monitor the T-cell clonotypes present in the different samples. Forty-three T-cell clonotypes were found infiltrating the XABCL tissue after three passes in mice along 6 months. Eighteen of these (42%) were also found in the TNBC biopsy. TCR infiltrating the XABCL tissue showed a very restricted T-cell repertoire as compared with the biopsy-infiltrating T cells. Consequently, T cells derived from the TNBC biopsy were expanded in the presence of the B-cell line obtained from the XABCL (XABCL-LCL), after which the TCR repertoire obtained was again very restricted, i.e., only certain clonotypes were selected by the B cells. A number of these TCRs had previously been reported as sequences involved in infection, cancer, and/or autoimmunity. We then analyzed the immunopeptidome from the XABCL-LCL, to identify putative B-cell-associated peptides that might have been expanding these T cells. The HLA class I and class II-associated peptides from XABCL-LCL were then compared with published repertoires from LCL of different HLA typing. Proteins from the antigen processing and presentation pathway remained significantly enriched in the XABCL-LCL repertoire. Interestingly, some class II-presented peptides were derived from cancer-related proteins. These results suggest that bystander tumor-infiltrating EBV+ B cells acting as APC may be able to interact with tumor-infiltrating T cells and influence the TCR repertoire in the tumor site. | - |
dc.description.sponsorship | This project was funded by Roche Farma, S.A. grant SP181123001 and the Spanish Ministry of Science, Innovation and Universities grant RTI2018-097414-B-I00. Partial financial support was received from the “El Paseíco de la Mama” 2015. This study received partial funding from Roche Farma, S.A. | - |
dc.language | eng | - |
dc.publisher | Frontiers Media | - |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-097414-B-I00/ES/MECANISMOS DE TOLERANCIA EN LA DIABETES DE TIPO 1: PROCESAMIENTO DE ANTIGENOS PEPTIDICOS Y LIPIDICOS Y MECANISMOS DE REGULACION EN TIMO Y EN PERIFERIA/ | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.subject | Epstein–Barr virus | - |
dc.subject | B cells, T cells | - |
dc.subject | Breast cancer | - |
dc.subject | TCR—T-cell receptor | - |
dc.title | Epstein–Barr Virus+ B Cells in Breast Cancer Immune Response: A Case Report | - |
dc.type | artículo | - |
dc.identifier.doi | 10.3389/fimmu.2021.761798 | - |
dc.relation.publisherversion | http://dx.doi.org/10.3389/fimmu.2021.761798 | - |
dc.date.updated | 2022-02-16T13:20:37Z | - |
dc.rights.license | https://creativecommons.org/licenses/by/4.0/ | - |
dc.contributor.funder | Roche | - |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | - |
dc.contributor.funder | Agencia Estatal de Investigación (España) | - |
dc.contributor.funder | Vall d'Hebron Research Institute | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/100004337 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011033 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.openairetype | artículo | - |
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