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Título: | Properties of polyplexes formed between a cationic polymer derived from l-arabinitol and nucleic acids |
Autor: | Pérez-Alonso, David; López-López, Manuel CSIC ORCID; López-Cornejo, Pilar; Romero-Azogil, Lucía; Benito, Elena; García-Martín, María de Gracia; García-Calderón, Clara B. CSIC ORCID; Rosado, Iván V. CSIC ORCID; Balestra, Fernando R.; Huertas Sánchez, Pablo CSIC ORCID; García-Calderón, Margarita; Moyá, María Luisa | Fecha de publicación: | 14-may-2021 | Editor: | Royal Society of Chemistry (UK) | Citación: | New Journal of Chemistry 45: 10098-10108 (2021) | Resumen: | In this work a sugar-based cationic polymer derived from l-arabinitol, PUArab, was prepared and its interactions with the linear calf thymus DNA and with the circular plasmid pEGFP-C1 were investigated at different N/P ratios. The polyplexes were characterized by using several techniques. For both nucleic acids, a charge inversion was observed, together with a conformational change from a coiled structure to a more compacted one. However, the N/P ratio required to observe the DNA condensation depended on the nucleic acid architecture. PUArab presents low toxicity in several cell lines. The transfection efficiency, TE, of the PUArab/pEGFP-C1 polyplexes was investigated at several N/P ratios in order to study their potential as vectors in gene transfection. | Versión del editor: | http://dx.doi.org/10.1039/d1nj00606a | URI: | http://hdl.handle.net/10261/259674 | DOI: | 10.1039/d1nj00606a | Identificadores: | doi: 10.1039/d1nj00606a e-issn: 1369-9261 issn: 1144-0546 |
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