Ferritin is associated with the aberrant tau filaments present in progressive supranuclear palsy

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Título:	Ferritin is associated with the aberrant tau filaments present in progressive supranuclear palsy
Autor:	Pérez, Mar CSIC ORCID; Valpuesta, José M. CSIC ORCID ; Montejo de Garcini, Esteban; Quintana, Carmen; Arrasate, Montserrat; Carrascosa, José L. CSIC ORCID; Rábano, Alberto; García de Yébenes, Justo; Ávila, Jesús CSIC ORCID
Fecha de publicación:	1998
Editor:	American Society for Investigative Pathology
Citación:	American Journal of Pathology 152(6): 1531-1539 (1998)
Resumen:	Tau-containing filaments purified from the brain of progressive supranuclear palsy (PSP) patients were isolated and characterized. These filaments co-purify with regular particles that biophysical and biochemical methods identified as ferritin shells. In vivo, brain tau accumulation in PSP co-localized with ferritin. These results suggest that ferritin/iron could modulate the formation of tau aggregates in PSP.
URI:	http://hdl.handle.net/10261/252014
ISSN:	0002-9440
Aparece en las colecciones:	(CBM) Artículos (CNB) Artículos (IMN-CNM) Artículos