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Título: | Synthesis and Antiviral Activity of 5’-O-Sulfamoyluridine Derivatives |
Autor: | Fiandor, José; García-López, M. Teresa CSIC ; Heras, F. G. de las; Méndez-Castrillón, Juan; Gil-Fernández, Carmen ; Pérez, Sara; Vilas, Pilar; Pérez, Concepción CSIC ORCID; García Gancedo, Angel CSIC | Fecha de publicación: | 1989 | Editor: | Taylor & Francis | Citación: | Nucleosides and Nucleotides 8(2): 257-271 (1989) | Resumen: | A series of 5′-O-[[[[(alkyl)oxy]carbonyl] amino] sulfonyl] uridines have been synthesized by reaction of cyclohexanol, palmityl alcohol, 1,2-di-O-benzoylpropanetriol and 2,3,4,6-tetra-O-benzoyl-L-glucopyranose with chlorosulfonyl isocyanate and 2,3′-O-isopropylidene-uridine. Another series of 5′-O-(N-ethyl and N-isopropylsulfamoyl) uridines have been prepared by reaction of 2′,3′-O-isopropylidene and 2′,3′-di-O-acetyluridine with N-ethylsulfamoyl and N-isopropylsulfamoyl chlorides. All compounds were tested against HSV-2, VV, SV and ASFV viruses. 2′,3′-Di-O-acetyl-5′-O-(N-ethyl and N-isopropylsulfamoyl) uridine showed significant activities against HSV-2. 5′-O-[[[[(2,3,4,6-Tetra-O-benzoyl-β-L-glucopyranosyl)oxy]carbonyl]amino] sulfonyl]-2′,3′-O-isopropylideneuridine was very active against ASFV. | Versión del editor: | http://dx.doi.org/10.1080/07328318908054171 | URI: | http://hdl.handle.net/10261/248766 | DOI: | 10.1080/07328318908054171 | Identificadores: | doi: 10.1080/07328318908054171 issn: 1525-7770 e-issn: 1532-2335 |
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