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Título: | SARS-CoV-2 fears green: the chlorophyll catabolite Pheophorbide a is a potent antiviral |
Autor: | Jiménez-Alemán, G. H.; Castro, Victoria; Longdaitsbehere, Addis; Gutiérrez-Rodríguez, Marta CSIC ORCID ; Garaigorta, Urtzi ; Gastaminza, Pablo CSIC ORCID; Solano, Roberto CSIC ORCID | Fecha de publicación: | 2-ago-2021 | Editor: | BioRxiv | Citación: | BioRxiv: 10.1101/2021.07.31.454592 (2021) | Resumen: | The SARS-CoV-2 pandemic is having devastating consequences worldwide. Although vaccination advances at good pace, effectiveness against emerging variants of the virus is unpredictable. The virus has displayed a remarkable resistance to treatments and no drugs have been proved fully effective against Covid-19. Thus, despite the international efforts, there is still an urgent need for new potent and safe antivirals against SARS-CoV-2. Here we exploited the enormous potential of plant metabolism, in particular the bryophyte Marchantia polymorpha, and following a bioactivity-guided fractionation and mass-spectrometry approach, identified a potent SARS-CoV-2 antiviral. We found that the chlorophyll derivative Pheophorbide a (PheoA), a natural porphyrin similar to animal Protoporphyrin IX, has an extraordinary antiviral activity against SARS-CoV-2 preventing infection of cultured monkey and human cells, without noticeable citotoxicity. We also show that PheoA prevents coronavirus entry into the cells by directly targeting the viral particle. Besides SARS-CoV-2, PheoA also displayed a broad-spectrum antiviral activity against (+)strand RNA viral pathogens such as HCV, West Nile, and other coronaviruses, but not against (-)strand RNA viruses, such as VSV. Our results indicate that PheoA displays a remarkable potency and a satisfactory therapeutic index, and suggest that it may be considered as a potential candidate for antiviral therapy against SARS-CoV-2. Moreover, PheoA adds to remdesivir's efficiency and is currently employed in photoactivable cancer therapies in humans. | Versión del editor: | https://doi.org/10.1101/2021.07.31.454592 | URI: | http://hdl.handle.net/10261/247074 | DOI: | 10.1101/2021.07.31.454592 |
Aparece en las colecciones: | (PTI Salud Global) Colección Especial COVID-19 (CNB) Artículos (IQM) Artículos |
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