Method and system for the analysis of analytes through mechanical resonance transduction

Abstract

The invention relates to a method and a system of mechanical resonance transduction for analyte analysis, suitable for its use in the identification of nanoparticles in the range between 1 MHz and 300 GHz, said method being characterized in that it comprises the following steps: a) disposing at least one analyte (1), possessing at least one mechanical vibration mode (1'), on at least one mechanical resonator sensor (2) that possesses at least one mechanical vibration mode (2'), selectable in a plurality of working frequencies; b) monitoring the mechanical spectra of the of the analyte (1) and the resonator sensor (2); c) varying the at least one mechanical vibration mode (2') until at least one mechanical vibration mode (2') reaches a strong coupling situation with the at least one mechanical vibration mode (1'); d) collecting the frequency data at which the strong coupling occurs; e) estimating the resonance frequency and quality factor of the at least one mechanical vibration mode (1') from the strong coupling frequency data obtained in step d)