Dataset related to article: Effects of second-generation antipsychotics on human subcutaneous adipose tissue metabolism

Abstract

Therapeutic concentrations of olanzapine and aripripazole have a moderate direct effect and adipocyte lipid and glucose metabolism, respectively. At supra-therapeutic concentrations, both of the antipsychotics seem to act as anti-inflammatory agents and mildly suppressed genes involved in the regulationof mitochondrial functions, which could potentially contribute to metabolic adverse effects. Alternatively, second generation antipsychotics could induce metabolic side effects via acting on other insulin-sensitive tissues and central nervous system.