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| Título: | Phosphorylation on the THR-248 and/or THR-250 residues of transcription factor E2F4 as a therapeutic target in pathological processes associated with somatic polyploidy |
Otros títulos: | Fosforilación en los residuos THR-248 y/o THR-250 del factor de transcripción E2F4 como diana terapéutica en procesos patológicos que cursan por poliplloidía somática | Autor: | Frade López, José María CSIC ORCID | Fecha de publicación: | 1-oct-2014 | Citación: | EP2783696 81 | Resumen: | The object of the invention is based on inhibiting specific phosphorylation on Thr248 and/or Thr250 residues of human transcription factor E2F4 to inhibit somatic endoreduplication processes in postmitotic cells which may be associated with various pathological conditions. The invention covers all currently known methods for the specific inhibition of protein phosphorylation (including the expression of mutant forms of E2F4 without Thr residues phosphorylated by p38MAPK) or methods developed in the future that may be applied to Thr-248 and/or Thr-250 residues of human transcription factor E2F4. | URI: | http://hdl.handle.net/10261/241361 |
| Aparece en las colecciones: | (IC) Patentes |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| EP2783696B1.pdf | Patente | 14,62 MB | Adobe PDF |  Visualizar/Abrir |
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