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Título: | Isolation and characterization of an exopolymer produced by Bacillus licheniformis: In vitro antiviral activity against enveloped viruses |
Autor: | Sánchez-León, Enrique; Bello-Morales, Raquel; López-Guerrero, José Antonio CSIC ORCID; Poveda, Ana; Jiménez-Barbero, Jesús CSIC ORCID; Gironès, Núria CSIC ORCID; Abrusci, C. CSIC ORCID | Palabras clave: | Bacillus licheniformis Poly(γ-glutamic acid) Teichoic acids Antiviral Enveloped viruses |
Fecha de publicación: | 3-jul-2020 | Editor: | Pergamon Press | Citación: | Carbohydrate Polymers 248 (2020) | Resumen: | The exopolymer (EPSp) produced by the strain B. licheniformis IDN-EC was isolated and characterized using different techniques (MALDI-TOF, NMR, ATR-FTIR, TGA, DSC, SEM). The results showed that the low molecular weight EPSp contained a long polyglutamic acid and an extracellular teichoic acid polysaccharide. The latter was composed of poly(glycerol phosphate) and was substituted at the 2-position of the glycerol residues with a αGal and αGlcNH. The αGal O-6 position was also found to be substituted by a phosphate group. The antiviral capability of this EPSp was also tested on both enveloped (herpesviruses HSV, PRV and vesicular stomatitis VSV) and non-enveloped (MVM) viruses. The EPSp was efficient at inhibiting viral entry for the herpesviruses and VSV but was not effective against non-enveloped viruses. The in vivo assay of the EPSp in mice showed no signs of toxicity which could allow for its application in the healthcare sector. | Versión del editor: | http://dx.doi.org/10.1016/j.carbpol.2020.116737 | URI: | http://hdl.handle.net/10261/237410 | DOI: | 10.1016/j.carbpol.2020.116737 | Identificadores: | doi: 10.1016/j.carbpol.2020.116737 issn: 0144-8617 |
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