Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/236053
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | A comparison of gene expression and DNA methylation patterns across tissues and species |
Autor: | Blake, Lauren E.; Roux, Julien; Hernando-Herraez, Irene CSIC ORCID; Banovich, Nick; García-Pérez, Raquel CSIC ORCID; Hsiao, Chiaowen Joyce; Eres, Ittai; Cuevas, Claudia; Marqués-Bonet, Tomàs CSIC ORCID ; Gilad, Yoav | Fecha de publicación: | 17-ene-2020 | Editor: | Cold Spring Harbor Laboratory Press | Citación: | Genome Research 30: 250-262 (2020) | Resumen: | Previously published comparative functional genomic data sets from primates using frozen tissue samples, including many data sets from our own group, were often collected and analyzed using nonoptimal study designs and analysis approaches. In addition, when samples from multiple tissues were studied in a comparative framework, individuals and tissues were confounded. We designed a multitissue comparative study of gene expression and DNA methylation in primates that minimizes confounding effects by using a balanced design with respect to species, tissues, and individuals. We also developed a comparative analysis pipeline that minimizes biases attributable to sequence divergence. Thus, we present the most comprehensive catalog of similarities and differences in gene expression and DNA methylation levels between livers, kidneys, hearts, and lungs, in humans, chimpanzees, and rhesus macaques. We estimate that overall, interspecies and inter-tissue differences in gene expression levels can only modestly be accounted for by corresponding differences in promoter DNA methylation. However, the expression pattern of genes with conserved inter-tissue expression differences can be explained by corresponding interspecies methylation changes more often. Finally, we show that genes whose tissue-specific regulatory patterns are consistent with the action of natural selection are highly connected in both gene regulatory and protein-protein interaction networks. | Versión del editor: | http://dx.doi.org/10.1101/gr.254904.119 | URI: | http://hdl.handle.net/10261/236053 | DOI: | 10.1101/gr.254904.119 | Identificadores: | doi: 10.1101/gr.254904.119 e-issn: 1549-5469 issn: 1088-9051 |
Aparece en las colecciones: | (IBE) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Genome Res.-2020-Blake-250-62.pdf | 2,47 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
53
checked on 25-abr-2024
SCOPUSTM
Citations
72
checked on 28-abr-2024
WEB OF SCIENCETM
Citations
69
checked on 29-feb-2024
Page view(s)
85
checked on 29-abr-2024
Download(s)
97
checked on 29-abr-2024