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Título: | Reduced graphene oxide membranes in ocular regenerative medicine |
Autor: | Zambrano-Andazol, Iriana; Vázquez, Natalia; Chacón, Manuel; Sánchez-Avila, Ronald M.; Persinal, Mairobi; Blanco Rodríguez, Clara CSIC ORCID ; González Arias, Zoraida CSIC ORCID ; Menéndez López, Rosa María CSIC ; Sierra, María; Fernández-Vega, Álvaro; Sánchez, Teresa; Meana, Álvaro | Palabras clave: | Reduced graphene oxide membrane GO biocompatibility ocular Regenerative Medicine Tissue Engineering: Ophthalmology |
Fecha de publicación: | 2020 | Editor: | Elsevier | Citación: | Materials Science and Engineering C- Materials for Biological Applications 114: 111075 (2020) | Resumen: | Biological membranes are currently used in Ophthalmology in order to treat different ocular disorders. These membranes have different properties such as cellular biocompatibility and promoting wound healing. Moreover, intrinsic antimicrobial properties could also be desirable because it would allow their use reducing the risk of infections. Graphene and its derivatives are promising biomaterials that already proved their bactericidal effect. However, their clinical use is limited due to the controversial results regarding their toxicity. In this work, we have developed and characterized a reduced graphene oxide membrane (rGOM) for its use in ocular Regenerative Medicine, and studied its in vitro and in vivo biocompatibility and genotoxicity with different types of human ocular cells. We proved that rGOM allowed the growth of different ocular cells without inducing in vitro or in vivo cytotoxicity or genotoxicity in the short-term. These results indicate that rGOM may be a promising candidate in Regenerative Medicine for the treatment of different ocular pathologies. | Versión del editor: | http://dx.doi.org/10.1016/j.msec.2020.111075 | URI: | http://hdl.handle.net/10261/233240 | DOI: | 10.1016/j.msec.2020.111075 | Identificadores: | doi: 10.1016/j.msec.2020.111075 issn: 1873-0191 |
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