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Título: | Role of Actin Cytoskeleton Reorganization in Polarized Secretory Traffic at the Immunological Synapse |
Autor: | Calvo, Victor CSIC ORCID; Izquierdo, Manuel CSIC ORCID | Palabras clave: | T lymphocytes B lymphocytes Immune synapse Actin cytoskeleton Protein kinase C δ Centrosomes Multivesicular bodies FMNL1 |
Fecha de publicación: | 4-feb-2021 | Editor: | Frontiers Media | Citación: | Frontiers in cell and developmental biology 9: 629097 (2021) | Resumen: | T cell receptor (TCR) and B cell receptor (BCR) stimulation by antigen presented on an antigen-presenting cell (APC) induces the formation of the immune synapse (IS), the convergence of secretory vesicles from T and B lymphocytes toward the centrosome, and the polarization of the centrosome to the immune synapse. Immune synapse formation is associated with an initial increase in cortical F-actin at the synapse, followed by a decrease in F-actin density at the central region of the immune synapse, which contains the secretory domain. These reversible, actin cytoskeleton reorganization processes occur during lytic granule degranulation in cytotoxic T lymphocytes (CTL) and cytokine-containing vesicle secretion in T-helper (Th) lymphocytes. Recent evidences obtained in T and B lymphocytes forming synapses show that F-actin reorganization also occurs at the centrosomal area. F-actin reduction at the centrosomal area appears to be involved in centrosome polarization. In this review we deal with the biological significance of both cortical and centrosomal area F-actin reorganization and some of the derived biological consequences. | Descripción: | © 2021 Calvo and Izquierdo. | Versión del editor: | http://dx.doi.org/10.3389/fcell.2021.629097 | URI: | http://hdl.handle.net/10261/231340 | DOI: | 10.3389/fcell.2021.629097 | E-ISSN: | 2296-634X |
Aparece en las colecciones: | (IIBM) Artículos |
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