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Título: | Identification of the first cases of complete CD16A deficiency: Association with persistent EBV infection |
Autor: | Pérez-Portilla, A.; Moraru, M.; Blázquez-Moreno, A.; Kolb, Philipp; García-Morato, María Bravo; Ranganath, Thanmayi; Esteso, Gloria; Gianelli, Carla; Rodríguez-Pena, Rebeca; Lozano-Rodríguez, Roberto; Torres-Canizales, Juan Manuel; Blish, Catherine A.; Valés-Gómez, Mar CSIC ORCID ; Hengel, Hartmut; Vilches, Carlos; López-Granados, Eduardo; Reyburn, H. T. | Fecha de publicación: | abr-2020 | Editor: | Elsevier | Citación: | Journal of Allergy and Clinical Immunology 145(4): 1288-1292 (2020) | Resumen: | During the clinical workup of an adolescent male with chronic active EBV disease, it was noted that natural killer (NK) cells of this individual did not express the Fc-receptor CD16A (Fig 1, A). The index patient, born to nonconsanguineous parents, was first seen when he was 11 years old, and an extended workup revealed persistently high levels of EBV-encoded small RNA (EBER) DNA in peripheral blood and multiple-organ infiltration with EBV-positive T lymphocytes including an IgA- and EBV-positive interstitial nephritis that eventually led to renal failure (see Case Report and Table E1 in this article’s Online Repository at www.jacionline.org). | Versión del editor: | http://dx.doi.org/10.1016/j.jaci.2019.11.049 | URI: | http://hdl.handle.net/10261/229230 | DOI: | 10.1016/j.jaci.2019.11.049 | ISSN: | 0091-6749 |
Aparece en las colecciones: | (CNB) Artículos |
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