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Título: | Characterization of the α-adrenergic stimulation of hepatic respiration |
Autor: | González-Manchón, Consuelo CSIC ORCID ; Saz, J. M.; Sánchez Ayuso, Matilde CSIC ORCID ; Parrilla, Roberto L. | Fecha de publicación: | sep-1988 | Editor: | Elsevier | Citación: | Archives of Biochemistry and Biophysics 265(2): 258-266 (1988) | Resumen: | The α-adrenergic agonist phenylephrine induces a biphasic stimulation of respiration in perfused isolated rat liver. The first phase, of rapid onset and short duration, is paralleled by increased glycogenolysis, glycolysis, and NAD redox potential. The second phase lasts for as long as the α-agonist is present and is accompanied by increased gluconeogenic flux. Only the second phase of sustained increased respiration is clearly dependent on extracellular Ca2+. In contrast, normal respiratory responses were obtained under Ca2+-loading conditions or in the presence of the Ca2+ ionophore A23187, indicating that the α-adrenergic action on respiration is not simply mediated by its ability to increase the cytosolic Ca2+ concentration. No stimulation of gluconeogenesis is observed in the absence of a sustained increase of respiration. However, it is not energy support that leads to the stimulation of glucose production. The adrenergic response is influenced by the nutritional status of the animal and the availability of oxidizable fuels. In livers from starved animals, the α-adrenergic respiratory response is abolished when long chain fatty acid oxidation is prevented by the addition of tetradecylglycidate. In the presence of pyruvate the respiratory response is partially restored. It is concluded that increased β-oxidation is not mandatory for the α-adrenergic stimulation of respiration; however, maximal respiratory responses are obtained only when fatty acid oxidation is allowed to proceed. The latter finding appears to be the result of a limited flux through the tricarboxylic acid cycle when long chain fatty acid oxidation is impeded, secondary to a limiting acetyl CoA supply. | Versión del editor: | https://doi.org/10.1016/0003-9861(88)90126-9 | URI: | http://hdl.handle.net/10261/226079 | DOI: | 10.1016/0003-9861(88)90126-9 | ISSN: | 0003-9861 |
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