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Título: | Deepening responses associated with improved progression-free survival with ixazomib versus placebo as posttransplant maintenance in multiple myeloma |
Autor: | Goldschmidt, Hartmut; Dimopoulos, Meletios A.; Rajkumar, S. Vincent; Weisel, Katja C.; Moreau, Philippe; Chng, Wee-Joo; Mikala, Gábor; Cavo, Michele; Ramasamy, Karthik; Suryanarayan, Kaveri; Teng, Zhaoyang; Labotka, Richard; Mateos, Maria Victoria | Fecha de publicación: | 2020 | Editor: | Springer Nature | Citación: | Leukemia 34: 3019-3027 (2020) | Resumen: | In the TOURMALINE-MM3 study, post-autologous stem cell transplantation maintenance therapy with the oral proteasome inhibitor ixazomib versus placebo significantly improved progression-free survival (PFS), with a favorable safety profile. With ixazomib versus placebo maintenance, deepening responses occurred in 139/302 (46%) versus 60/187 (32%) patients with very good partial response or partial response (VGPR/PR) at study entry (relative risk 1.41, P = 0.004), and median time to best confirmed deepened response was 19.9 versus 30.8 months (24-month rate: 54.2 versus 41.4%; hazard ratio (HR): 1.384; P = 0.0342). Median PFS in patients with VGPR/PR at study entry was 26.2 versus 18.5 months (HR: 0.636, P < 0.001) with ixazomib versus placebo; in a pooled analysis across arms, in patients with versus without deepening responses, the median PFS was not reached versus 15.9 months (HR: 0.245, P < 0.001). In patients with deepening responses, 24-month PFS rate was 77.4 versus 68.3% with ixazomib versus placebo (HR: 0.831; P = 0.466); in patients without deepening responses, median PFS was 17.9 versus 14.1 months (HR: 0.741; P = 0.028). These analyses demonstrate the significantly higher rate of deepening responses with ixazomib versus placebo maintenance and the association between deepening response and prolonged PFS. | Versión del editor: | https://doi.org/10.1038/s41375-020-0819-8 | URI: | http://hdl.handle.net/10261/222773 | DOI: | 10.1038/s41375-020-0819-8 | E-ISSN: | 1476-5551 |
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