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dc.contributor.authorPineda-Pampliega, Javieres_ES
dc.contributor.authorHerrera-Dueñas, Amparoes_ES
dc.contributor.authorMulder, Ellises_ES
dc.contributor.authorAguirre, Jose Ignacioes_ES
dc.contributor.authorHöfle, Ursulaes_ES
dc.contributor.authorVerhulst, Simones_ES
dc.date.accessioned2020-10-20T06:58:16Z-
dc.date.available2020-10-20T06:58:16Z-
dc.date.issued2020-
dc.identifier.citationProceedings of the Royal Society of London - B: 287: 20191917 (2020)es_ES
dc.identifier.issn0962-8452-
dc.identifier.urihttp://hdl.handle.net/10261/221384-
dc.description.abstractTelomere length (TL) and shortening is increasingly shown to predict variation in survival and lifespan, raising the question of what causes variation in these traits. Oxidative stress is well known to accelerate telomere attrition in vitro, but its importance in vivo is largely hypothetical. We tested this hypothesis experimentally by supplementing white stork (Ciconia ciconia) chicks with antioxidants. Individuals received either a control treatment, or a supply of tocopherol (vitamin E) and selenium, which both have antioxidant properties. The antioxidant treatment increased the concentration of tocopherol for up to two weeks after treatment but did not affect growth. Using the telomere restriction fragment technique, we evaluated erythrocyte TL and its dynamics. Telomeres shortened significantly over the 21 days between the baseline and final sample, independent of sex, mass, size and hatching order. The antioxidant treatment significantly mitigated shortening rate of average TL (−31% in shorter telomeres; percentiles 10th, 20th and 30th). Thus, our results support the hypothesis that oxidative stress shortens telomeres in vivo.es_ES
dc.description.sponsorshipDiego San Mauro for his financial support for the telomere assays (Project CGL2017-85637-P financed by the Spanish Ministry of Economy and Competitiveness). Fieldwork for this study and oxidative stress assays were partly supported by project RTA2011-00111-C03-02 financed by the Spanish National Institute for Agricultural Research INIA. J.P.-P. was funded by a grant from the Complutense University of Madrid (CT45/15-CT46/15).es_ES
dc.language.isoenges_ES
dc.publisherRoyal Society (Great Britain)es_ES
dc.relationMICIU/ICTI2017-2020/CGL2017-85637-Pes_ES
dc.relationCGL2017-85637-P/AEI/10.13039/501100011033es_ES
dc.rightsclosedAccesses_ES
dc.titleAntioxidant supplementation slows telomere shortening in free-living white stork chickses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1098/rspb.2019.1917-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1098/rspb.2019.1917es_ES
dc.identifier.e-issn1471-2954-
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)es_ES
dc.contributor.funderAgencia Estatal de Investigación (España)es_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderInstituto Nacional de Investigación y Tecnología Agraria y Alimentaria (España)es_ES
dc.contributor.funderUniversidad Complutense de Madrides_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100011033es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100007652es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100002911es_ES
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