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http://hdl.handle.net/10261/221384
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Pineda-Pampliega, Javier | es_ES |
dc.contributor.author | Herrera-Dueñas, Amparo | es_ES |
dc.contributor.author | Mulder, Ellis | es_ES |
dc.contributor.author | Aguirre, José I. | es_ES |
dc.contributor.author | Höfle, Ursula | es_ES |
dc.contributor.author | Verhulst, Simon | es_ES |
dc.date.accessioned | 2020-10-20T06:58:16Z | - |
dc.date.available | 2020-10-20T06:58:16Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Proceedings of the Royal Society of London - B: 287: 20191917 (2020) | es_ES |
dc.identifier.issn | 0962-8452 | - |
dc.identifier.uri | http://hdl.handle.net/10261/221384 | - |
dc.description.abstract | Telomere length (TL) and shortening is increasingly shown to predict variation in survival and lifespan, raising the question of what causes variation in these traits. Oxidative stress is well known to accelerate telomere attrition in vitro, but its importance in vivo is largely hypothetical. We tested this hypothesis experimentally by supplementing white stork (Ciconia ciconia) chicks with antioxidants. Individuals received either a control treatment, or a supply of tocopherol (vitamin E) and selenium, which both have antioxidant properties. The antioxidant treatment increased the concentration of tocopherol for up to two weeks after treatment but did not affect growth. Using the telomere restriction fragment technique, we evaluated erythrocyte TL and its dynamics. Telomeres shortened significantly over the 21 days between the baseline and final sample, independent of sex, mass, size and hatching order. The antioxidant treatment significantly mitigated shortening rate of average TL (−31% in shorter telomeres; percentiles 10th, 20th and 30th). Thus, our results support the hypothesis that oxidative stress shortens telomeres in vivo. | es_ES |
dc.description.sponsorship | Diego San Mauro for his financial support for the telomere assays (Project CGL2017-85637-P financed by the Spanish Ministry of Economy and Competitiveness). Fieldwork for this study and oxidative stress assays were partly supported by project RTA2011-00111-C03-02 financed by the Spanish National Institute for Agricultural Research INIA. J.P.-P. was funded by a grant from the Complutense University of Madrid (CT45/15-CT46/15). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Royal Society (Great Britain) | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/CGL2017-85637-P | es_ES |
dc.relation | CGL2017-85637-P/AEI/10.13039/501100011033 | es_ES |
dc.rights | closedAccess | es_ES |
dc.title | Antioxidant supplementation slows telomere shortening in free-living white stork chicks | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1098/rspb.2019.1917 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1098/rspb.2019.1917 | es_ES |
dc.identifier.e-issn | 1471-2954 | - |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación (España) | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.contributor.funder | CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA) | es_ES |
dc.contributor.funder | Universidad Complutense de Madrid | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011033 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100002911 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100007652 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.pmid | 31937223 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.grantfulltext | none | - |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
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