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http://hdl.handle.net/10261/220272
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dc.contributor.author | León, Patricia de | - |
dc.contributor.author | Cañas-Arranz, Rodrigo | - |
dc.contributor.author | Saez, Yago | - |
dc.contributor.author | Forner, Mar | - |
dc.contributor.author | Defaus, Sira | - |
dc.contributor.author | Cuadra, Dolores | - |
dc.contributor.author | Bustos, Maria José | - |
dc.contributor.author | Torres, Elisa | - |
dc.contributor.author | Andreu, David | - |
dc.contributor.author | Blanco Lavilla, Esther | - |
dc.contributor.author | Sobrino Castelló, Francisco | - |
dc.contributor.author | Hammer, Sabine E. | - |
dc.date.accessioned | 2020-09-25T13:32:21Z | - |
dc.date.available | 2020-09-25T13:32:21Z | - |
dc.date.issued | 2020-09-08 | - |
dc.identifier.citation | Vaccines 8(3): 513 (2020) | - |
dc.identifier.uri | http://hdl.handle.net/10261/220272 | - |
dc.description.abstract | Dendrimer peptides are promising vaccine candidates against the foot-and-mouth disease virus (FMDV). Several B-cell epitope (B2T) dendrimers, harboring a major FMDV antigenic B-cell site in VP1 protein, are covalently linked to heterotypic T-cell epitopes from 3A and/or 3D proteins, and elicited consistent levels of neutralizing antibodies and IFN-γ-producing cells in pigs. To address the contribution of the highly polymorphic nature of the porcine MHC (SLA, swine leukocyte antigen) on the immunogenicity of B2T dendrimers, low-resolution (Lr) haplotyping was performed. We looked for possible correlations between particular Lr haplotypes with neutralizing antibody and T-cell responses induced by B2T peptides. In this study, 63 pigs immunized with B2T dendrimers and 10 non-immunized (control) animals are analyzed. The results reveal a robust significant correlation between SLA class-II Lr haplotypes and the T-cell response. Similar correlations of T-cell response with SLA class-I Lr haplotypes, and between B-cell antibody response and SLA class-I and SLA class-II Lr haplotypes, were only found when the sample was reduced to animals with Lr haplotypes represented more than once. These results support the contribution of SLA class-II restricted T-cells to the magnitude of the T-cell response and to the antibody response evoked by the B2T dendrimers, being of potential value for peptide vaccine design against FMDV. | - |
dc.description.sponsorship | This work was supported by the Spanish Ministry of Science, Innovation and Universities (grant AGL2017-89097-C2 to F.S. and D.A.; AGL2016-76445-R to E.B.; PGC2018-096849-B-I00 to Y.S. and D.C.), Comunidad de Madrid co-financed with ECFEDER funds (P2018/BAA-4370 to F.S. and E.B.) and Generalitat de Catalunya (2009SGR492 to D.A.). Work at Centro de Biología Molecular “Severo Ochoa” and at UPF was supported by Fundación Ramón Areces and by the Maria de Maeztu Program of the Spanish Ministry of Science, Innovation and Universities, respectively. R. Cañas-Arranz and M. Forner were holders of a PhD fellowship from the Spanish Ministry of Science, Innovation and University (FPI programme). | - |
dc.publisher | Multidisciplinary Digital Publishing Institute | - |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/AGL2017-89097-C2 | - |
dc.relation | AGL2017-89097-C2/AEI/10.13039/501100011033 | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2016-76445-R | - |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PGC2018-096849-B-I00 | - |
dc.relation | PGC2018-096849-B-I00/AEI/10.13039/501100011033 | - |
dc.relation | P2018/BAA-4370 | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.subject | swine | - |
dc.subject | foot-and-mouth disease virus | - |
dc.subject | dendrimer peptide | - |
dc.subject | swine leukocyte antigen | - |
dc.subject | SLA polymorphism | - |
dc.subject | Adaptive immunity | - |
dc.subject | vaccine | - |
dc.subject | Protection | - |
dc.title | Association of porcine swine leukocyte antigen (SLA) haplotypes with B- and T-cell immune response to foot-and-mouth disease virus (FMDV) peptides | - |
dc.type | artículo | - |
dc.identifier.doi | 10.3390/vaccines8030513 | - |
dc.description.peerreviewed | Peer reviewed | - |
dc.relation.publisherversion | https://doi.org/10.3390/vaccines8030513 | - |
dc.identifier.e-issn | 2076-393X | - |
dc.date.updated | 2020-09-25T13:32:22Z | - |
dc.rights.license | http://creativecommons.org/licenses/by/4.0/ | - |
dc.contributor.funder | Comunidad de Madrid | - |
dc.contributor.funder | Generalitat de Catalunya | - |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | - |
dc.contributor.funder | Agencia Estatal de Investigación (España) | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Fundación Ramón Areces | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100012818 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100008054 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100002809 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011033 | es_ES |
dc.identifier.pmid | 32911818 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
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SLA_haplotypes_B_T-cell_immune_FMDV_Peptides.pdf | 3,11 MB | Adobe PDF | Visualizar/Abrir |
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