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Título: | Inhibitory gating in the Dentate Gyrus |
Autor: | Estarellas, Cristian CSIC ORCID; Mirasso, Claudio R. CSIC ORCID ; Canals, Santiago CSIC ORCID | Fecha de publicación: | 2019 | Citación: | 18th National Meeting of the Spanish Society of Neuroscience (2019) | Resumen: | -Electrophysiological recordings have demonstrated the existence of a tight inhibitory control of hilar interneurons over Dentate Gyrus granule cells (DGgc). -Our experiments show that LTP induced in the perforant pathway (PP) potentiates glutamatergic synapses and reduces feed-foward inhibition in the DG. -To investigate this phenomenon we implemented a model that includes entorhinal cortex (EC) neurons, DGgc, mossy cells, basket cells and Hil cells. -Our results show that the increase of the glutamatergic inputs results in a net inhibition of the basket cell population. -Results of the model are supported by experiments in vitro where the LTP has been performed in vivo, obtaining this effect in the slice without antagonist GABAa. -Our findings suggest that LTP applied at the EC outputs modifies the excitation/inhibition balance in the Dentate Gyrus facilitating communication with CA3. | Descripción: | Trabajo presentado al 18th National Meeting of the Spanish Society of Neuroscience (SENC), celebrado en Santiago de Compostela del 4 al 6 de septiembre de 2019. | URI: | http://hdl.handle.net/10261/218196 |
Aparece en las colecciones: | (IFISC) Comunicaciones congresos (IN) Comunicaciones congresos |
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dentagyru.pdf | 2,48 MB | Adobe PDF | Visualizar/Abrir |
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