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Título: | The role of ACKR3 in breast, lung, and brain cancer |
Autor: | Neves, María; Fumagalli, Amos; Van den Bor, Jelle; Marin, Philippe; Smit, Martine J.; Mayor Méndez, Federico Jr. | Fecha de publicación: | 30-ene-2019 | Editor: | American Society for Pharmacology and Experimental Therapeutics | Citación: | Molecular Pharmacology 96: 819- 825 (2019) | Resumen: | Recent reports regarding the significance of chemokine receptors in disease have put a spotlight on atypical chemokine receptor 3 (ACKR3). This atypical chemokine receptor is overexpressed in numerous cancer types and has been involved in the modulation of tumor cell proliferation and migration, tumor angiogenesis, or resistance to drugs, thus contributing to cancer progression and metastasis occurrence. Here, we focus on the clinical significance and potential mechanisms underlying the pathologic role of ACKR3 in breast, lung, and brain cancer and discuss its possible relevance as a prognostic factor and potential therapeutic target in these contexts. | Versión del editor: | http://dx.doi.org/10.1124/mol.118.115279 | URI: | http://hdl.handle.net/10261/216350 | DOI: | 10.1124/mol.118.115279 | Identificadores: | doi: 10.1124/mol.118.115279 issn: 1521-0111 |
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MayorJrF_TheRoleofACKR3.pdf | 482,5 kB | Adobe PDF | Visualizar/Abrir |
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