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Título: | Epigenetic Deregulation in Human Primary Immunodeficiencies |
Autor: | Campos-Sánchez, Elena CSIC ORCID ; Martínez-Cano, Jorge; Pino Molina, Lucía del; López-Granados, Eduardo; Cobaleda, César CSIC ORCID | Fecha de publicación: | 2019 | Editor: | Elsevier BV | Citación: | Trends in Immunology 40: 49- 65 (2019) | Resumen: | Primary immunodeficiencies (PIDs) are immune disorders resulting from defects in genes involved in immune regulation, and manifesting as an increased susceptibility to infections, autoimmunity, and cancer. However, the molecular basis of some prevalent entities remains poorly understood. Epigenetic control is essential for immune functions, and epigenetic alterations have been identified in different PIDs, including syndromes such as immunodeficiency-centromeric-instability-facial-anomalies, Kabuki, or Wolf–Hirschhorn, among others. Although the epigenetic changes may differ among these PIDs, the reversibility of epigenetic modifications suggests that they might become potential therapeutic targets. Here, we review recent mechanistic advances in our understanding of epigenetic alterations associated with certain PIDs, propose that a fully epigenetically driven mechanism might underlie some PIDs, and discuss the possible prophylactic and therapeutic implications. | Versión del editor: | http://dx.doi.org/10.1016/j.it.2018.11.005 | URI: | http://hdl.handle.net/10261/214519 | DOI: | 10.1016/j.it.2018.11.005 | Identificadores: | doi: 10.1016/j.it.2018.11.005 issn: 1471-4981 |
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CobaledaC_EpigeneticDeregulation.pdf | 2,93 MB | Adobe PDF | Visualizar/Abrir |
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