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http://hdl.handle.net/10261/199749
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dc.contributor.author | Adarsh, Nayarassery N. | es_ES |
dc.contributor.author | Frias, Carolina | es_ES |
dc.contributor.author | Ponnoth Lohidakshan, T. M. | es_ES |
dc.contributor.author | Lorenzo, Julia | es_ES |
dc.contributor.author | Novio, Fernando | es_ES |
dc.contributor.author | García-Pardo, Javier | es_ES |
dc.contributor.author | Ruiz Molina, Daniel | es_ES |
dc.date.accessioned | 2020-02-05T11:26:47Z | - |
dc.date.available | 2020-02-05T11:26:47Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Chemical Engineering Journal 340: 94-102 (2018) | es_ES |
dc.identifier.issn | 1385-8947 | - |
dc.identifier.uri | http://hdl.handle.net/10261/199749 | - |
dc.description.abstract | Cisplatin has been for many years the gold standard chemotherapeutic drug for the treatment of a wide range of solid tumors, even though its use is commonly associated with serious side effects including non-selective toxicity, myelosuppression or development of cisplatin resistance, among others complications. Over the last decade, a number of nanoparticle formulations were developed to reduce its side effects and improve the selectivity and efficacy of this drug. In this study, we have developed a novel nanoparticle platform based on nanoscale coordination polymer named (Zn-Pt(IV)-NCPs) which contains a Pt(IV) prodrug, Zn and the linker ligand 1,4-Bis(imidazol-1-ylmethyl)benzene (bix). The main objective has been to gain insights into the mechanism of action of this nanostructured material in comparison with cisplatin and the free Pt(IV) prodrug in order to establish a correlation between nanostructuration and therapeutic activity. Zn-Pt(IV)-NCPs nanoparticles displayed an average size close to 200 nm as determined by DLS, a good stability in physiologic environments, and a controlled drug release of Pt. In vitro studies demonstrated that Pt(IV)-NCPs showed an enhanced cytotoxic effect against cell culture of cervical cancer, neuroblastoma and human adenocarcinoma cells in comparison with free Pt(IV) prodrug. Although no difference in cell uptake of Pt was observed for any of the three cell lines assayed, a higher amount of Pt bound to the DNA was found in the cells treated with the nanostructured Pt(IV) prodrug. These studies suggest that the nanostructuration of the prodrug facilitate its activation and induce a change in the mechanism of action related to an increased interaction with the DNA as corroborated by the studies of direct interaction of the Pt(IV) prodrug, nanostructured or not, with DNA. | es_ES |
dc.description.sponsorship | This work was supported by project MAT2012-38318-C03-02, MAT2015-70615-R, BIO2013-44973-R and BIO2016-78057-R from the Spanish Government and by FEDER – European Commission funds. ICN2 acknowledges support from the Severo Ochoa Programme of the Spanish Ministry of Economy, Industry and Competitiveness (MINECO, Grant SEV-2013-0295). The ICN2 is funded by the CERCA programme/Generalitat de Catalunya. Authors would also like to acknowledge the support of the TRANSAUTOPHAGY COST Action, CA15138. NNA thanks the EU for a Marie Curie Intra-European Fellowship (FP6-MC-IEF-629703). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2015-70615-R | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BIO2013-44973-R | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BIO2016-78057-R | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SEV-2013-0295 | es_ES |
dc.rights | closedAccess | es_ES |
dc.subject | Nanoscale coordination polymers | es_ES |
dc.subject | Cisplatin | es_ES |
dc.subject | Nanoparticles | es_ES |
dc.subject | Platinum | es_ES |
dc.title | Pt(IV)-based nanoscale coordination polymers: Antitumor activity, cellular uptake and interactions with nuclear DNA | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1016/j.cej.2018.01.058 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.cej.2018.01.058 | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | Ministerio de Economía, Industria y Competitividad (España) | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | Generalitat de Catalunya | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100010198 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100002809 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | artículo | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
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