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Title

3-(Aminomethyl)-2-(carboxymethyl)isoxazolidinyl nucleosides: building blocks for peptide nucleic acid analogues

AuthorsMerino, Pedro ; Tejero, Tomás ; Matés, Juan; Chiacchio, Ugo; Corsaro, Antonio; Romeo, Giovanni
Issue Date17-Jun-2007
PublisherElsevier
CitationTetrahedron Asymmetry 18(13): 1517-1520 (2007)
AbstractThe synthesis of orthogonally protected 3-(aminomethyl)-2-(carboxymethyl)isoxazolidinyl thymine, a convenient monomer for the preparation of novel isoxazolidinyl peptide nucleic acid analogues, has been achieved through enantioselective 1,3-dipolar cycloaddition between N-glycosyl nitrones and vinyl acetate.
Description4 pages, 3 schemes, 1 table, 1 chart.
Publisher version (URL)http://dx.doi.org/10.1016/j.tetasy.2007.06.029
URIhttp://hdl.handle.net/10261/19225
DOI10.1016/j.tetasy.2007.06.029
ISSN0957-4166
Appears in Collections:(ICMA) Artículos
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