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Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Elena, Santiago F. | - |
dc.contributor.author | Gómez, Gustavo | - |
dc.contributor.author | Daròs Arnau, José Antonio | - |
dc.date.accessioned | 2009-11-10T12:28:42Z | - |
dc.date.available | 2009-11-10T12:28:42Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Viruses 1: 241-254 | en_US |
dc.identifier.uri | http://hdl.handle.net/10261/18450 | - |
dc.description.abstract | We suggest that viroids are trapped into adaptive peaks as the result of adaptive constraints. The first one is imposed by the necessity to fold into packed structures to escape from RNA silencing. This creates antagonistic epistases, which make future adaptive trajectories contingent upon the first mutation and slow down the rate of adaptation. This second constraint can only be surpassed by increasing genetic redundancy or by recombination. Eigen’s paradox imposes a limit to the increase in genome complexity in the absence of mechanisms reducing mutation rate. Therefore, recombination appears as the only possible route to evolutionary innovation in viroids. | en_US |
dc.description.sponsorship | This work has been supported by grants BFU2006-14819-C02-01/BMC (S.F.E.) and BIO2008- 01986 (J.A.D.) from the Spanish Ministerio de Ciencia e Innovación. | en_US |
dc.format.extent | 630259 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | en_US |
dc.publisher | Multidisciplinary Digital Publishing Institute | en_US |
dc.rights | openAccess | - |
dc.subject | viroids | en_US |
dc.subject | viroids evolution | en_US |
dc.subject | epistasis | en_US |
dc.subject | evolutionary constraints | en_US |
dc.subject | genome complexity | en_US |
dc.subject | RNA folding | en_US |
dc.title | Evolutionary constraints to viroid evolution | en_US |
dc.type | artículo | - |
dc.identifier.doi | 10.3390/v1020241 | - |
dc.description.peerreviewed | Peer reviewed | en_US |
dc.relation.publisherversion | http://dx.doi.org/10.3390/v1020241 | en_US |
dc.identifier.pmid | 21994548 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairetype | artículo | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
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Elena et al Viruses.pdf | 615,49 kB | Adobe PDF | Visualizar/Abrir |
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