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http://hdl.handle.net/10261/184326
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Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Martínez-Florensa, Mario | es_ES |
dc.contributor.author | Consuegra-Fernández, Marta | es_ES |
dc.contributor.author | Aranda, Fernando | es_ES |
dc.contributor.author | Armiger-Borràs, Noelia | es_ES |
dc.contributor.author | Di Scala, Marianna | es_ES |
dc.contributor.author | Carrasco, Esther | es_ES |
dc.contributor.author | Pachón, Jerónimo | es_ES |
dc.contributor.author | Vila, Jordi | es_ES |
dc.contributor.author | González-Aseguinolaza, Gloria | es_ES |
dc.contributor.author | Lozano, Francisco | es_ES |
dc.date.accessioned | 2019-06-18T07:30:28Z | - |
dc.date.available | 2019-06-18T07:30:28Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Antimicrobial Agents and Chemotherapy 61: 01391-16 (2017) | es_ES |
dc.identifier.issn | 0066-4804 | - |
dc.identifier.uri | http://hdl.handle.net/10261/184326 | - |
dc.description.abstract | Sepsis still constitutes an unmet clinical need, which could benefit from novel adjunctive strategies to conventional antibiotic therapy. The soluble form of the scavenger-like human CD6 lymphocyte receptor (shCD6) binds to key pathogenic components from Gram-positive and -negative bacteria and shows time- and dose-dependent efficacy in mouse models of monobacterial sepsis. The objective of the present work was to demonstrate the effectiveness of infusing mouse and human sCD6 by different systemic routes, either alone or as adjunctive therapy to gold standard antibiotics, in a lethal model of polymicrobial sepsis. To this end, C57BL/6 mice undergoing high-grade septic shock induced by cecal ligation and puncture (CLP; ≥90% lethality) were infused via the intraperitoneal (i.p.) or intravenous (i.v.) route with shCD6 at different doses and time points, either alone or in combination with imipenem/cilastatin (I/C) at a dose of 33 mg/kg of body weight every 8 h. Significantly reduced mortality and proinflammatory cytokine levels were observed by i.p. infusion of a single shCD6 dose (1.25 mg/kg) 1 h pre- or post-CLP. When using the i.v. route, mice survival was significantly extended by starting shCD6 infusion at later time points post-CLP (up to 6 h after CLP). Significant adjunctive effects on mouse survival were observed by i.p. or i.v. infusion of shCD6 in combination with i.p. I/C post-CLP. Similar results were obtained in mice expressing high sustained levels (5 to 10 μg/ml) of mouse sCD6 in serum by means of transduction with hepatotropic adeno-associated virus (AAV). Taken together, the data support the conserved antibacterial effects of human and mouse sCD6 and their use as adjunctive therapy in experimental models of complex and severe polymicrobial sepsis. | es_ES |
dc.description.sponsorship | This work was supported by grants from the Spanish Ministerio de Economía y Competitividad (Plan Nacional de I+D+i, SAF2013-46151-R), Instituto de Salud Carlos III (ISCIII)-cofinanced by European Development Regional Fund “A way to achieve Europe” ERDF (Spanish Network for Research in Infectious Diseases, REIPI, RD12/0015/0018), and Fundació La Marató TV3 (201319-30-31). F.A. is recipient of a Sara Borrell fellowship (CD15/00016) from ISCIII. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Society for Microbiology | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2013-46151-R | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PCIN-2015-070 | - |
dc.relation.isreferencedby | Martínez-Florensa, Mario ; Consuegra-Fernández, Marta; Aranda, Fernando; Armiger-Borràs, Noelia; Di Scala, Marianna; Carrasco, Esther ; Pachón, Jerónimo ; Vila, Jordi; González-Aseguinolaza, Gloria; Lozano, Francisco. Erratum for Martínez-Florensa et al., “Protective Effects of Human and Mouse Soluble Scavenger-Like CD6 Lymphocyte Receptor in a Lethal Model of Polymicrobial Sepsis”. https://doi.org/10.1128/AAC.01997-17 . http://hdl.handle.net/10261/184330 | - |
dc.rights | closedAccess | es_ES |
dc.subject | Soluble CD6 | es_ES |
dc.subject | Cecal ligation and puncture | es_ES |
dc.subject | Polymicrobial peritonitis | es_ES |
dc.subject | Scavenger receptors | es_ES |
dc.subject | Sepsis | es_ES |
dc.subject | Septic shock | es_ES |
dc.subject | Adjunctive therapy | es_ES |
dc.title | Protective Effects of Human and Mouse Soluble Scavenger-Like CD6 Lymphocyte Receptor in a Lethal Model of Polymicrobial Sepsis | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1128/AAC.01391-16 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1128/AAC.01391-16 | es_ES |
dc.identifier.e-issn | 1098-6596 | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | Red Española de Investigación en Patología Infecciosa | es_ES |
dc.contributor.funder | Fundació La Marató de TV3 | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/100008666 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.pmid | 27895015 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | artículo | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
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