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Title

Gut microbiota, cannabinoid system and neuroimmune interactions: New perspectives in multiple sclerosis

AuthorsMestre, Leyre ; Carrillo-Salinas, F. J.; Mecha, Miriam ; Feliú, Ana; Guaza, Carmen
KeywordsCannabinoid system
Gut microbiota
Autoimmunity
TMEV-IDD
Multiple sclerosis
Issue DateNov-2018
PublisherElsevier
CitationBiochemical Pharmacology 157: 51-66 (2018)
AbstractThe gut microbiota plays a fundamental role on the education and function of the host immune system. Immunological dysregulation is the cause of numerous human disorders such as autoimmune diseases and metabolic disorders frequently associated with inflammatory processes therefore is critical to explore novel mechanisms involved in maintaining the immune system homeostasis. The cannabinoid system and related bioactive lipids participate in multiple central and peripheral physiological processes that affect metabolic, gastrointestinal and neuroimmune regulatory mechanisms displaying a modulatory role and contributing to the maintenance of the organism’s homeostasis. In this review, we gather the knowledge on the gut microbiota-endocannabinoids interactions and their impact on autoimmune disorders such as inflammatory bowel disease, rheumatoid arthritis and particularly, multiple sclerosis (MS) as the best example of a CNS autoimmune disorder. Furthermore, we contribute to this field with new data on changes in many elements of the cannabinoid system in a viral model of MS after gut microbiota manipulation by both antibiotics and probiotics. Finally, we highlight new therapeutic opportunities, under an integrative view, targeting the eCBS and the commensal microbiota in the context of neuroinflammation and MS.
Publisher version (URL)https://doi.org/10.1016/j.bcp.2018.08.037
URIhttp://hdl.handle.net/10261/183195
DOI10.1016/j.bcp.2018.08.037
ISSN0006-2952
Appears in Collections:(IC) Artículos
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