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http://hdl.handle.net/10261/181345
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Picard-Sánchez, Amparo | es_ES |
dc.contributor.author | Estensoro, Itziar | es_ES |
dc.contributor.author | Pozo, R. del | es_ES |
dc.contributor.author | Piazzon de Haro, María Carla | es_ES |
dc.contributor.author | Palenzuela, Oswaldo | es_ES |
dc.contributor.author | Sitjà-Bobadilla, Ariadna | es_ES |
dc.date.accessioned | 2019-05-14T07:03:26Z | - |
dc.date.available | 2019-05-14T07:03:26Z | - |
dc.date.issued | 2019-07 | - |
dc.identifier.citation | Fish & Shellfish Immunology 90: 349-362 (2019) | es_ES |
dc.identifier.issn | 1050-4648 | - |
dc.identifier.uri | http://hdl.handle.net/10261/181345 | - |
dc.description.abstract | The myxozoan parasite Enteromyxum leei causes chronic enteritis in gilthead sea bream (GSB, Sparus aurata) leading to intestinal dysfunction. Two trials were performed in which GSB that had survived a previous infection with E. leei (SUR), and naïve GSB (NAI), were exposed to water effluent containing parasite stages. Humoral factors (total IgM and IgT, specific anti-E. leei IgM, total serum peroxidases), histopathology and gene expression were analysed. Results showed that SUR maintained high levels of specific anti-E. leei IgM (up to 16 months), expressed high levels of immunoglobulins at the intestinal mucosa, particularly the soluble forms, and were resistant to re-infection. Their acquired-type response was complemented by other immune effectors locally and systemically, like cell cytotoxicity (high granzyme A expression), complement activity (high c3 and fucolectin expression), and serum peroxidases. In contrast to NAI, SUR displayed a post-inflammatory phenotype in the intestine and head kidney, characteristic of inflammation resolution (low il1β, high il10 and low hsp90α expression). | es_ES |
dc.description.sponsorship | This study was supported by EU H2020 program and by the Spanish Ministry of Economy and Competitiveness through ParaFishControl (634429) and AGL-2013-48560-R research projects, respectively. This publication reflects the views only of the authors, and the European Commission cannot be held responsible for any use which may be made of the information contained therein. MCP was contracted under CSIC PIE project no. 201740E013 and IE was recipient of APOSTD/2016/037 grant by the “Generalitat Valenciana”. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/634429 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2013-48560-R | es_ES |
dc.relation.isversionof | Postprint | es_ES |
dc.rights | openAccess | en_EN |
dc.subject | Acquired immune response | es_ES |
dc.subject | Fish IgM | es_ES |
dc.subject | Sparus aurata | es_ES |
dc.subject | Enteromyxum leei | es_ES |
dc.subject | Parasite resistance | es_ES |
dc.subject | Gene expression | es_ES |
dc.title | Acquired protective immune response in a fish-myxozoan model encompasses specific antibodies and inflammation resolution | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1016/j.fsi.2019.04.300 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.fsi.2019.04.300 | es_ES |
dc.identifier.e-issn | 1095-9947 | - |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.contributor.funder | Consejo Superior de Investigaciones Científicas (España) | es_ES |
dc.contributor.funder | Generalitat Valenciana | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003359 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003339 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairetype | artículo | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
Aparece en las colecciones: | (IATS) Artículos |
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REPOSITORIO FSI_2019_Accepted_manuscript.pdf | 14,17 MB | Adobe PDF | Visualizar/Abrir |
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