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Closed Access item Characterization of possible correlates of protective response against Brucella ovis infection in rams immunized with the B. melitensis Rev 1 vaccine

Authors:Galindo, Ruth C.
Muñoz, Pilar M.
Miguel, María J. de
Marín, Clara M.
Blasco, José M.
Gortázar, Christian
Kocan, Katherine M.
Fuente García, José de la
Keywords:Brucella, Vaccine, Sheep, Microarray, Genomics
Issue Date:7-Apr-2009
Publisher:Elsevier
Citation:Vaccine 27(23): 3039-3044 (2009)
Abstract:Vaccination with the live attenuated Brucella melitensis Rev 1 vaccine is used to control ovine brucellosis caused by Brucella ovis in sheep. The objective of this study was to identify possible correlates of protective response to B. ovis infection through the characterization by microarray hybridization and real-time RT-PCR of inflammatory and immune response genes differentially expressed in rams previously immunized with B. melitensis Rev 1 and experimentally challenged with B. ovis. Gene expression profiles were compared before and after challenge with B. ovis between rams protected and those vaccinated but found infected after challenge. The TLR10, Bak and ANXI genes were expressed at higher levels in vaccinated and protected rams. These genes provide possible correlates of protective response to B. ovis infection in rams immunized with the B. melitensis Rev 1 vaccine.
Description:6 pages, 2 figures, 2 tables.-- PMID: 19428917 [PubMed].-- Printed version published May 18, 2009.
Publisher version (URL):http://dx.doi.org/10.1016/j.vaccine.2009.03.046
URI:http://hdl.handle.net/10261/18109
ISSN:0264-410X
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Appears in Collections:(IREC) Artículos

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