Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/180313
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Carballo, Rubén M. | - |
dc.contributor.author | León, Leticia G. | - |
dc.contributor.author | Quijano-Quiñones, Ramiro F. | - |
dc.contributor.author | Mena-Rejón, Gonzalo J. | - |
dc.contributor.author | Martín, Víctor S. | - |
dc.contributor.author | Padrón, José M. | - |
dc.contributor.author | Padrón, Juan I. | - |
dc.date.accessioned | 2019-04-22T10:24:42Z | - |
dc.date.available | 2019-04-22T10:24:42Z | - |
dc.date.issued | 2014 | - |
dc.identifier | doi: 10.2174/1573406409666131124231552 | - |
dc.identifier | issn: 1573-4064 | - |
dc.identifier | e-issn: 1875-6638 | - |
dc.identifier.citation | Medicinal Chemistry 10(6): 571-579 (2014) | - |
dc.identifier.uri | http://hdl.handle.net/10261/180313 | - |
dc.description.abstract | A series of functionalized N-sulfonyl-piperidines and N-sulfonyl-tetrahydropyridines were evaluated for their antiproliferative activity against the representative panel of human solid tumor cells A2780 (ovarian), SW1573 (non-small cell lung) and WiDr (colon). The SAR study showed for WiDr cells a correlation between the biological activity and the length of the N-sulfonyl group, the nature of the substituents and the type of alkyl side chain. Further QSAR studies indicate that the size and nature of the N-sulfonyl group, the atomic polarizability (MP) and the partition coefficient are the most important descriptors for the activity. The major contribution is the size (F05C-S) of the N-sulfonyl group. | - |
dc.publisher | Bentham Science Publishers | - |
dc.rights | closedAccess | - |
dc.subject | Piperidine | - |
dc.subject | Iron Catalyst | - |
dc.subject | Prins Cyclization | - |
dc.subject | QSAR | - |
dc.subject | Aza-cycle | - |
dc.subject | Antiproliferative activity | - |
dc.title | Antiproliferative evaluation of N-sulfonyl-2-Alkyl-six membered azacycles. A QSAR study | - |
dc.type | artículo | - |
dc.identifier.doi | 10.2174/1573406409666131124231552 | - |
dc.relation.publisherversion | http://dx.doi.org/10.2174/1573406409666131124231552 | - |
dc.date.updated | 2019-04-22T10:24:42Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.relation.csic | Sí | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
Aparece en las colecciones: | (IPNA) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
2
checked on 05-may-2024
WEB OF SCIENCETM
Citations
2
checked on 26-feb-2024
Page view(s)
230
checked on 10-may-2024
Download(s)
49
checked on 10-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.