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dc.contributor.authorGalicia, N.-
dc.contributor.authorDégano, Rosa M.-
dc.contributor.authorDíez, Paula-
dc.contributor.authorGonzález González, María-
dc.contributor.authorGóngora, Rafael-
dc.contributor.authorIbarrola, Nieves-
dc.contributor.authorFuentes, Manuel-
dc.date.accessioned2018-08-28T10:27:47Z-
dc.date.available2018-08-28T10:27:47Z-
dc.date.issued2017-
dc.identifierdoi: 10.1080/14789450.2017.1307106-
dc.identifiere-issn: 1744-8387-
dc.identifierissn: 1478-9450-
dc.identifier.citationExpert Review of Proteomics 14(4): 363-372 (2017)-
dc.identifier.urihttp://hdl.handle.net/10261/169203-
dc.description.abstract[Introduction]: Leptomeningeal metastases (LM) from lymphoma remain a difficult complication for oncologist due to the high incidence in morbidity and mortality. Early diagnostic and initiation of treatment are essential to prevent neurological deterioration. [Areas covered]: In this review, several proteomic approaches are described in order to help and provide the basis for the identification of biomarkers useful in early diagnosis, also in discovery novel targets for therapeutic agents. In fact, the identification of biomarkers will have a high potential to detect leptomeningeal lymphoma, as well as to predict its progression and treatment response. [Expert commentary]: In the case of LM by Central nervous system (CNS) lymphoma, these studies generated the first insights into the utility of proteomic analysis for biomarker identification and will be demonstrated that identifying specific proteins in cerebrospinal fluid (CSF) had much greater sensitivity for detecting LM in comparison to standard cytological protocols.-
dc.description.sponsorshipWe gratefully acknowledge financial support from the Spanish Health Institute Carlos III (ISCIII) [FIS PI114/01538]. We also acknowledge Fondos FEDER (EU), Junta Castilla-León [grant BIO/SA07/15] and Fundación Solórzano [FS23/2015]. The Proteomics Unit belongs to ProteoRed, PRB2-ISCIII [PT13/0001], of the PE I+D+I 2013-2016, funded by ISCIII and FEDER. N.G. is supported by Consejo Nacional de Ciencia y Tecnología (CONACYT) and P.D. is supported by a JCYL Ph.D. scholarship [EDU/346/2013].-
dc.publisherTaylor & Francis-
dc.rightsclosedAccess-
dc.subjectLeptomeningeal lymphoma-
dc.subjectCerebrospinal fluid-
dc.subjectProteins-
dc.subjectProteomics-
dc.subjectBiomarkers-
dc.titleCSF analysis for protein biomarker identification in patients with leptomeningeal metastases from CNS lymphoma-
dc.typeArtículo-
dc.date.updated2018-08-28T10:27:48Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.contributor.funderInstituto de Salud Carlos III-
dc.contributor.funderConsejo Nacional de Ciencia y Tecnología (México)-
dc.contributor.funderFundación Memoria de D. Samuel Solorzano Barruso-
dc.contributor.funderJunta de Castilla y León-
dc.contributor.funderEuropean Commission-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003141es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.pmid28293970-
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