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http://hdl.handle.net/10261/167935
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dc.contributor.author | Jiménez, Aranza | - |
dc.contributor.author | García, Pablo | - |
dc.contributor.author | Puente-Secades, Sofía de la | - |
dc.contributor.author | Madrona, Andrés | - |
dc.contributor.author | Camarasa Rius, María José | - |
dc.contributor.author | Peréz-Pérez, María-Jesús | - |
dc.contributor.author | Quintela Fernández, José Carlos | - |
dc.contributor.author | García del Portillo, Francisco | - |
dc.contributor.author | San-Félix, Ana | - |
dc.date.accessioned | 2018-07-25T12:42:18Z | - |
dc.date.available | 2018-07-25T12:42:18Z | - |
dc.date.issued | 2018-06-22 | - |
dc.identifier.citation | Molecules 23(7): 1513 (2018) | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | http://hdl.handle.net/10261/167935 | - |
dc.description.abstract | Cationic and non-peptide small molecules containing a total of six positive charges arranged on one side and a long aliphatic tail on the other have been synthesized and tested against Gram-positive and Gram-negative bacteria. The positive charges have been contributed by two aminophenol residues. These molecules have showed remarkable antimicrobial activity against Gram-positive bacteria including multidrug-resistant strains. Our structure–activity relationship studies demonstrated the importance of the length and flexibility of the hydrophobic tail for the antimicrobial activity. Importantly, these compounds are non-toxic to eukaryotic cells at the concentration affecting growth in bacteria, reflecting an acceptable margin of safety. The small size and easy synthetic accessibility of our molecules can be of interest for the further development of novel antimicrobials against Gram-positive bacterial pathogens, including multidrug-resistant strains. | - |
dc.description.sponsorship | This research was funded by the Spanish “Plan Nacional de Cooperación Público-Privada, Subprograma INNPACTO” project number IPT-2012-0213 060000, cofinanced by the FEDER program (to J.-C.Q., F.G.-d.P, A.S.-F. and M.-J.P.-P.), “Ministerio de Economia, Industria y Competitividad, Gobierno de España” and “European Regional Development Funds” projects numbers SAF2015-64629-C2-1-R (MINECO/FEDER) (to A.S.-F., M.-J.C. and M.-J.P.-P.) and BIO2016-77639-P (MINECO/FEDER) (to F.G.-d.P.). The Spanish MEC/MINECO is also acknowledged for Garantía Juvenil contracts to A.J. and S.d.l.P. | - |
dc.publisher | Multidisciplinary Digital Publishing Institute | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2015-64629-C2-1-R | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BIO2016-77639-P | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.subject | Antimicrobial agents | - |
dc.subject | Antibiotic resistance | - |
dc.subject | Antimicrobial peptides | - |
dc.title | A Novel Class of Cationic and Non-Peptidic Small Molecules as Hits for the Development of Antimicrobial Agents | - |
dc.type | artículo | - |
dc.identifier.doi | 10.3390/molecules23071513 | - |
dc.description.peerreviewed | Peer reviewed | - |
dc.relation.publisherversion | https://doi.org/10.3390/molecules23071513 | - |
dc.date.updated | 2018-07-25T12:42:19Z | - |
dc.rights.license | http://creativecommons.org/licenses/by/4.0/ | - |
dc.contributor.funder | Ministerio de Economía, Industria y Competitividad (España) | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100010198 | es_ES |
dc.identifier.pmid | 29932141 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.openairetype | artículo | - |
item.fulltext | With Fulltext | - |
Aparece en las colecciones: | (IQM) Artículos (CNB) Artículos |
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molecules-23-01513-v2.pdf | 4,52 MB | Adobe PDF | Visualizar/Abrir |
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