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dc.contributor.authorGetino, Maríaes_ES
dc.contributor.authorPalencia-Gándara, Carolinaes_ES
dc.contributor.authorCruz, Fernando de laes_ES
dc.identifier.citationPlasmid Biology 2016es_ES
dc.descriptionResumen del trabajo presentado al Plasmid Biology Meeting, celebrado en Cambridge (UK) del 18 al 23 de septiembre de 2016.es_ES
dc.description.abstractInfections due to antibiotic-resistant enterobacteria are a worldwide cause of morbidity and mortality. Antibiotic resistance genes disseminate mostly by conjugative plasmids. Plasmid conjugation could be controlled by mechanisms naturally displayed by bacteria. Among them, fertility inhibition systems prevent conjugation of co-resident plasmids in donor cells. The study of interactions between conjugative systems could provide useful information to fight against antibiotic resistance dissemination. In this work, conjugation ability of IncW broad host range plasmids was analyzed in the presence of a representative set of co-resident plasmids. Two novel fertility inhibition systems against R388 conjugation were discovered in IncFI plasmid pOX38 and IncI1 plasmid R64. The precise mechanism of inhibition is being investigated. Interestingly, when R388 was substituted by a reduced synthetic version, these effects diminished two orders of magnitude, whereas the effects caused by other fertility inhibition systems encoded by IncP1α and IncX2 plasmids were maintained. This kind of knowledge could also be valuable for constructing bacterial computing devices employing conjugative plasmids as wires.es_ES
dc.titleFertility inhibition between conjugative plasmidses_ES
dc.typecomunicación de congresoes_ES
dc.description.peerreviewedPeer reviewedes_ES
oprm.item.hasRevisionno ko 0 false*
Appears in Collections:(IBBTEC) Comunicaciones congresos
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