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http://hdl.handle.net/10261/163333
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Dobrzynska, Agnieszka | - |
dc.contributor.author | Askjaer, Peter | - |
dc.contributor.author | Gruenbaum, Yosef | - |
dc.date.accessioned | 2018-04-09T11:07:41Z | - |
dc.date.available | 2018-04-09T11:07:41Z | - |
dc.date.issued | 2016 | - |
dc.identifier | doi: 10.1016/bs.mie.2015.08.036 | - |
dc.identifier | issn: 0076-6879 | - |
dc.identifier | e-issn: 1557-7988 | - |
dc.identifier.citation | Methods in Enzymology 569: 455-483 (2016) | - |
dc.identifier.uri | http://hdl.handle.net/10261/163333 | - |
dc.description.abstract | The nuclear lamina, composed of lamins and numerous lamin-associated proteins, is required for mechanical stability, mechanosensing, chromatin organization, developmental gene regulation, mRNA transcription, DNA replication, nuclear assembly, and nuclear positioning. Mutations in lamins or lamin-binding proteins cause at least 18 distinct human diseases that affect specific tissues such as muscle, adipose, bone, nerve, or skin, and range from muscular dystrophies to lipodystrophy, peripheral neuropathy, or accelerated aging. Caenorhabditis elegans has unique advantages in studying lamin-binding proteins. These advantages include the low complexity of genes encoding lamin and lamin-binding proteins, advanced transgenic techniques, simple application of RNA interference, sophisticated genetic strategies, and a large collection of mutant lines. This chapter provides detailed and comprehensive protocols for the genetic and phenotypic analysis of lamin-binding proteins in C. elegans. | - |
dc.description.sponsorship | We gratefully acknowledge Georgina Gómez-Saldivar for discussion on the DamID protocol and funding from the Muscular Dystrophy Association (MDA), the Binational Israel-USA Science Foundation (BSF 2007215), and the Niedersachsen-Israeli Research Cooperation program to Y.G. and funding from the Spanish Ministry of Economy and Competitiveness (BFU2013-42709P), the Autonomous Government of Andalusia (P08-CVI-3920), and the European Regional Development Fund to P.A. | - |
dc.publisher | Elsevier | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2013-42709-P | - |
dc.rights | closedAccess | - |
dc.subject | BAF-1 | - |
dc.subject | ChIP | - |
dc.subject | CRISPR | - |
dc.subject | DamID | - |
dc.subject | FRET | - |
dc.subject | Emerin | - |
dc.subject | Lamin | - |
dc.subject | FLIP | - |
dc.title | Lamin binding proteins in Caenorhabditis elegans | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1016/bs.mie.2015.08.036 | - |
dc.date.updated | 2018-04-09T11:07:41Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | Muscular Dystrophy Association (US) | - |
dc.contributor.funder | Junta de Andalucía | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | United States-Israel Binational Science Foundation | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100005202 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100001742 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011011 | es_ES |
dc.identifier.pmid | 26778571 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
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