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http://hdl.handle.net/10261/161282
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Chalupniak, Andrzej | - |
dc.contributor.author | Merkoçi, Arben | - |
dc.date.accessioned | 2018-02-26T10:38:31Z | - |
dc.date.available | 2018-02-26T10:38:31Z | - |
dc.date.issued | 2017 | - |
dc.identifier | doi: 10.1007/s12274-016-1420-3 | - |
dc.identifier | e-issn: 1998-0000 | - |
dc.identifier | issn: 1998-0124 | - |
dc.identifier.citation | Nano Research 10(7): 2296-2310 (2017) | - |
dc.identifier.uri | http://hdl.handle.net/10261/161282 | - |
dc.description.abstract | A novel, miniaturized microfluidic platform was developed for the simultaneous detection and removal of polybrominated diphenyl ethers (PBDEs). The platform consists of a polydimethylsiloxane (PDMS) microfluidic chip for an immunoreaction step, a PDMS chip with an integrated screen-printed electrode (SPCE) for detection, and a PDMS-reduced graphene oxide (rGO) chip for physical adsorption and subsequent removal of PBDE residues. The detection was based on competitive immunoassay-linked binding between PBDE and PBDE modified with horseradish peroxidase (HRP-PBDE) followed by the monitoring of enzymatic oxidation of o-aminophenol (o-AP) using square wave anodic stripping voltammetry (SW-ASV). PBDE was detected with good sensitivity and a limit of detection similar to that obtained with a commercial colorimetric test (0.018 ppb), but with the advantage of using lower reagent volumes and a reduced analysis time. The use of microfluidic chips also provides improved linearity and a better reproducibility in comparison to those obtained with batch-based measurements using screen-printed electrodes. In order to design a detection system suitable for toxic compounds such as PBDEs, a reduced graphene oxide–PDMS composite was developed and optimized to obtain increased adsorption (based on both the hydrophobicity and π–π stacking between rGO and PBDE molecules) compared to those of non-modified PDMS. To the best of our knowledge, this is the first demonstration of electrochemical detection of flame retardants and a novel application of the rGO-PDMS composite in a biosensing system. This system can be easily applied to detect any analyte using the appropriate immunoassay and it supports operation in complex matrices such as seawater. | - |
dc.description.sponsorship | We acknowledge FP7 EU Project “SMS” (No. 613844). ICN2 acknowledges support from the Severo Ochoa Program (MINECO, No. SEV-2013-0295) and Secretaria d’Universitats i Recerca del Departament d′Economia i Coneixement de la Generalitat de Catalunya (2014 SGR 260). | - |
dc.publisher | Springer Nature | - |
dc.publisher | Tsinghua University Press | - |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/613844 | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SEV-2013-0295 | - |
dc.rights | closedAccess | - |
dc.subject | Microfluidics | - |
dc.subject | Flame retardants | - |
dc.subject | Graphene oxide | - |
dc.subject | Lab on a chip | - |
dc.subject | Electrochemistry | - |
dc.subject | Polydimethylsiloxane | - |
dc.title | Toward integrated detection and graphene-based removal of contaminants in a lab-on-a-chip platform | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1007/s12274-016-1420-3 | - |
dc.date.updated | 2018-02-26T10:38:31Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.contributor.funder | Generalitat de Catalunya | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100002809 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | artículo | - |
Aparece en las colecciones: | (CIN2) Artículos |
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