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| Título: | Cerium oxide nanoparticles reduce steatosis, portal hypertension and display anti-inflammatory properties in rats with liver fibrosis |
Autor: | Oró, Denise; Yudina, Tetyana CSIC ORCID; Casals, Eudald CSIC ORCID; Puntes, Víctor F. CSIC ORCID; Jiménez, Wladimiro | Palabras clave: | Oxidative stress Cerium oxide nanoparticles Portal pressure Hepatic inflammation Experimental fibrosis |
Fecha de publicación: | 2016 | Editor: | Elsevier | Citación: | Journal of Hepatology 64(3): 691-698 (2016) | Resumen: | [Background & Aims]: Cerium oxide nanoparticles (CeONPs) have proven to behave as free radical scavengers and/or anti-inflammatory agents. The aim of the study was to determine whether CeONPs display hepatoprotective properties in experimental chronic liver disease. [Methods]: Systemic and hepatic effects of nanoparticles were assessed in CCl-treated rats receiving CeONPs or vehicle twice weekly for two weeks and CCl treatment was continued for 8 additional weeks. Thereafter, mean arterial pressure and portal pressure (PP) were assessed and serum samples obtained to measure standard hepatic and renal function tests. Organ and subcellular distribution of NPs were assessed using mass spectrometry (ICP-MS) and transmission electron microscopy. Liver samples were obtained to evaluate steatosis, α-SMA expression, macrophage infiltration, apoptosis and mRNA expression of oxidative stress, inflammatory or vasoactive related genes. [Results]: Most CeONPs were located in the liver and it reduced hepatic steatosis, ameliorated systemic inflammatory biomarkers and improved PP without affecting mean arterial pressure. In addition, a marked reduction in mRNA expression of inflammatory cytokines (TNFα, IL1β, COX-2, iNOS), ET-1 and messengers related to oxidative (Epx, Ncf1, Ncf2) or endoplasmic reticulum (Atf3, Hspa5) stress signaling pathways was observed in the liver of rats receiving CeONPs. This was associated with reduced macrophage infiltration and reduced abundance of caspase-3, α-SMA and inflammatory cytokines. [Conclusions]: CeONPs administration to CCl-treated rats protects against chronic liver injury by reducing liver steatosis and portal hypertension and markedly attenuating the intensity of the inflammatory response, thereby suggesting that CeONPs may be of therapeutic value in chronic liver disease. | Descripción: | et al. | URI: | http://hdl.handle.net/10261/159340 | DOI: | 10.1016/j.jhep.2015.10.020 | Identificadores: | doi: 10.1016/j.jhep.2015.10.020 e-issn: 1600-0641 issn: 0168-8278 |
| Aparece en las colecciones: | (CIN2) Artículos |
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