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Título: | In vivo anticancer activity, toxicology and histopathological studies of the thiolate gold(I) complex [Au(Spyrimidine)(PTA-CH2Ph)]Br |
Autor: | García-Moreno, Elena CSIC; Gascón, Sonia; García de Jalón, José A.; Romanos, Eduardo; Rodríguez-Yoldi, Mª. Jesus; Cerrada, Elena CSIC ORCID; Laguna, Mariano CSIC ORCID | Fecha de publicación: | 2015 | Editor: | Bentham Science Publishers | Citación: | Anti-Cancer Agents in Medicinal Chemistry 15(6): 773-782 (2015) | Resumen: | A physiologically stable thiolate gold(I) derivative [Au(Spyrimidine)(PTA-CH2Ph)]Br has shown inhibition in colon cancer proliferation of Caco-2/TC7, Caco-2/PD7 and HTC-116-luc2 cell lines via apoptotic pathway and S-phase arrest in the cell cycle. Intraperitoneal injection of [Au(Spyrimidine)(PTA-CH2Ph)]Br in athymic nude mice inoculated with HTC-116-luc2 cells prolonged their survival and greatly inhibited tumour growth, near to disappearance. Low concentration of gold in urine and blood were detected in mice after 48 h of administration of 5 mg/kg body weight (bw) of the gold complex and non-organ (kidney and liver) damage has been detected after gold treatment. The results obtained suggested that the thiolate gold(I) derivative shown here could be considered as a candidate for therapeutic treatment in colon cancer. | URI: | http://hdl.handle.net/10261/154710 | DOI: | 10.2174/1871520615666150129211440 | Identificadores: | doi: 10.2174/1871520615666150129211440 e-issn: 1875-5992 issn: 1871-5206 |
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