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Título: | Cytoplasmic 5′-3′ exonuclease Xrn1p is also a genome-wide transcription factor in yeast |
Autor: | Medina, Daniel A.; Jordán-Pla, Antonio CSIC ORCID; Millán-Zambrano, Gonzalo CSIC ORCID; Chávez, Sebastián CSIC ORCID; Choder, Mordechai; Pérez-Ortín, José Enrique | Fecha de publicación: | 6-feb-2014 | Editor: | Frontiers Media | Citación: | Front. Genet. 5: 1 (2014) | Resumen: | The 5′ to 3′ exoribonuclease Xrn1 is a large protein involved in cytoplasmatic mRNA degradation as a critical component of the major decaysome. Its deletion in the yeast Saccharomyces cerevisiae is not lethal, but it has multiple physiological effects. In a previous study, our group showed that deletion of all tested components of the yeast major decaysome, including XRN1, results in a decrease in the synthetic rate and an increase in half-life of most mRNAs in a compensatory manner. Furthermore, the same study showed that the all tested decaysome components are also nuclear proteins that bind to the 5′ region of a number of genes. In the present work, we show that disruption of Xrn1 activity preferentially affects both the synthesis and decay of a distinct subpopulation of mRNAs. The most affected mRNAs are the transcripts of the highly transcribed genes, mainly those encoding ribosome biogenesis and translation factors. Previously, we proposed that synthegradases play a key role in regulating both mRNA synthesis and degradation. Evidently, Xrn1 functions as a synthegradase, whose selectivity might help coordinating the expression of the protein synthetic machinery. We propose to name the most affected genes “Xrn1 synthegradon.” | Versión del editor: | http://dx.doi.org/10.3389/fgene.2014.00001 Publisher's version |
URI: | http://hdl.handle.net/10261/153163 | DOI: | 10.3389/fgene.2014.00001 | ISSN: | 1664-8021 |
Aparece en las colecciones: | (IBIS) Artículos |
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