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http://hdl.handle.net/10261/153021
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Popa, Crina | - |
dc.contributor.author | Tabuchi, Mitsuaki | - |
dc.contributor.author | Valls, Marc | - |
dc.date.accessioned | 2017-07-14T11:56:19Z | - |
dc.date.available | 2017-07-14T11:56:19Z | - |
dc.date.issued | 2016-07-20 | - |
dc.identifier.citation | Front. Cell. Infect. Microbiol. 6: 73 (2016) | - |
dc.identifier.issn | 2235-2988 | - |
dc.identifier.uri | http://hdl.handle.net/10261/153021 | - |
dc.description.abstract | Pathogenic bacteria manipulate their hosts by delivering a number of virulence proteins -called effectors- directly into the plant or animal cells. Recent findings have shown that such effectors can suffer covalent modifications inside the eukaryotic cells. Here, we summarize the recent reports where effector modifications by the eukaryotic machinery have been described. We restrict our focus on proteins secreted by the type III or type IV systems, excluding other bacterial toxins. We describe the known examples of effectors whose enzymatic activity is triggered by interaction with plant and animal cell factors, including GTPases, E2-Ubiquitin conjugates, cyclophilin and thioredoxins. We focus on the structural interactions with these factors and their influence on effector function. We also review the described examples of host-mediated post-translational effector modifications which are required for proper subcellular location and function. These host-specific covalent modifications include phosphorylation, ubiquitination, SUMOylation, and lipidations such as prenylation, fatty acylation and phospholipid binding. | - |
dc.description.sponsorship | This work was funded by projects AGL2013-46898-R (MINECO, Spain) to MV and COST Action FA1208 Sustain funded by the European Union H2020. This work was also supported by Japan Society of the Promotion of Science KAKENHI Grant 16K07668. | - |
dc.publisher | Frontiers Media | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.title | Modification of Bacterial Effector Proteins Inside Eukaryotic Host Cells | - |
dc.type | artículo | - |
dc.identifier.doi | 10.3389/fcimb.2016.00073 | - |
dc.description.peerreviewed | Peer reviewed | - |
dc.relation.publisherversion | http://dx.doi.org/10.3389/fcimb.2016.00073 | - |
dc.date.updated | 2017-07-14T11:56:19Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | Copyright © 2016 Popa, Tabuchi and Valls. | - |
dc.rights.license | http://creativecommons.org/licenses/by/4.0/ | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Japan Society for the Promotion of Science | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100001691 | es_ES |
dc.identifier.pmid | 27489796 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.openairetype | artículo | - |
item.fulltext | With Fulltext | - |
Aparece en las colecciones: | (CRAG) Artículos |
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Fichero | Descripción | Tamaño | Formato | |
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Modification of Bacterial Effector Proteins.pdf | 1,25 MB | Adobe PDF | Visualizar/Abrir |
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