Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/148266
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | In vitro cell cytotoxicity profile and morphological response to polyoxometalate-stabilised gold nanoparticles |
Autor: | Maicas Gabas, Isabel; Stepien, Grazyna; Ruíz del Árbol, María; Mitchell, Scott G. CSIC ORCID; Fuente, Jesús M. de la CSIC ORCID | Fecha de publicación: | 2016 | Editor: | Royal Society of Chemistry (UK) | Citación: | New Journal of Chemistry 40(2): 1039-1047 (2016) | Resumen: | The size and redox properties of molecular polyoxometalates (POMs) make them extremely relevant for bioapplications: from disrupting tumour growth and enzyme inhibition, to DNA-intercalating agents and antimicrobial applications. Their unique ability to reversibly dominate and receive electrons, coupled with their high anionic charge, also makes them suitable for the preparation of zero-valent state metal nanoparticles (NPs) from molecular precursors. Polyoxometalate-stabilised nanoparticles (NPs@POM) are therefore an ideal delivery vehicle for bioactive POMs. Here we show how POM-stabilised gold NPs (AuNPs@POM) are massively internalised into Vero (kidney epithelial) and B16 (skin melanoma) cell lines with variable cytotoxic effects. Cell viability assays and quantification of cytoplasmic membrane composition revealed that the Vero cell line was unaltered by the internalisation of these hybrid particles; while their internalisation in B16 tumour cells produced mild cytotoxic effects and an antiproliferative cell cycle arrest in the G0/G1 and G2/M phases. The observed perturbation of the tumour cell line combined with the high degree of internalisation means that these (or similar) NPs@POM could serve as candidates for a range of bioapplications in diagnostics or therapy. | URI: | http://hdl.handle.net/10261/148266 | DOI: | 10.1039/c5nj02775f | Identificadores: | doi: 10.1039/c5nj02775f e-issn: 1369-9261 issn: 1144-0546 |
Aparece en las colecciones: | (ICMA) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
18
checked on 25-abr-2024
WEB OF SCIENCETM
Citations
15
checked on 27-feb-2024
Page view(s)
232
checked on 26-abr-2024
Download(s)
84
checked on 26-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.